P53

Stanislaw Burzynski, MD, PhD, the founder of antineoplaston treatment and therapy, has claimed to have treated hundreds of cancer patients in America and Mexico. Antineoplastons are a group of naturally- occurring peptides formed in the body through blood and urine which control tumor growth, and have been proven as a means of an alternative treatment, in respect to the toxins in chemotherapy (Reismann, 3). More than almost forty years later, after the beginning of antineoplastons, published…

The effect of opium on diethylnitrosamine-induced gastrointestinal cancer in rats Uncontrolled growth of abnormal cells and their spreading to another tissues ,these characterizing of cancers which mostly lead to death ,if their spreading is not controlled.Cancers are caused by chemical materials ,infectious organisms,tobacco and radiation as external factors and hormones,mutation and immune conditions as internal factors.(1) Gastrointestinal cancers are the term for many cancers which…

progression and cell division by way of regulating a series of related genes, such as PAK1, DIAPH2, CDK6 and CDC25.(17) The human miR-34 family consists of miR-34a, miR-34b, and miR-34c. The miR-34 miRNAs are tumor suppressors and are vital mediators in the p53 pathway. In specific, it has been proven that the miR-34 family members decrease cell…

Introduction Cancer is a disease whereby cells undergo changes that cause them to grow uncontrollably1. These changes are caused by gene mutations2. Genes are sections of deoxyribonucleic acid (DNA), contained within every cell2. Genes control which proteins are synthesised and which cells should be destroyed2. Each type of cancer is classified according to the site where the cancer initiated, i.e. the location of initial gene mutation3. Malignant melanoma is a skin cancer whereby the…

INTRODUCTION Cancer can be defined as a special kind of illness that occurs when the cells in a given part of a body begin to grow out of proportion than is normal. Currently, in the United States, this disease is the second leading cause of deaths. Human beings over the history have had tumors and remedies have been implemented, and others continue to be performed and studied over time (American Cancer Society, 2010). These methods of treatment include chemo-preventive methods and of late…

BRCA1 and BRCA2 genetic testing, should everyone do it? Introduction Cancer happens when the cells in the body grow out of control and make tumors. This procedure is organized by biochemical in different parts of the body. (7) Breast cancer is the most common cancer among all the woman and about 5-10 percent of breast cancers are heritable. (9) Mutation in BRCA genes is responsible for 25 percent Inherent Breast cancer. Breast cancer is affected by so many risk factors. Every year about 233,000…

directions 1. In this study, the in vitro assays based on human cell lines were used to evaluate the toxicity of several common cellular responses and toxic effects. The toxicity evaluation of mixtures can be extended to other endpoints like apoptosis, p53 mediated DNA damage, metal stress response and other adaptive responses for a more comprehensive understanding of adverse…

BRCA1 and BRCA2 genetic testing, should everyone do it? Shahrzad Eslamian Purpose: For a person with a positive mutation in BRCA1 or BRCA2, the chance of getting breast cancer increases by 50-60 percent.1 This causes concern for some women and makes them take a BRCA1/2 mutation test to make sure they are not carrying this mutation. In September 2015, a research from UCLA was published that indicated some debate over whether or not testing BRCA genes is worth the cost.4 This paper will be…

1. Introduction: Squamous cell carcinoma of the head and neck (SCCHN) can be ranked as the sixth leading cancer by incidence worldwide (1,2). Every year, there are more than 550,000 patients diagnosed with head and neck cancers worldwide and around 300,000 related deaths (3). Squamous cell carcinomas represent 90% of cases and mostly arise from the epithelial lining of the oral cavity, oropharynx, larynx, and hypopharynx. SCCHN can be divided into three stages: early stage (I/II), locally…

This may cause accumulation of errors rapidly in the cell and its progeny. * Those in signaling (endocrine) machinery of the cell. This leads transmission of the error signals to nearby healthy cells as well. * Those that allow the cells to migrate and disrupt more healthy cells away from the primary site of origin. * Those that make the cell immortal so that the abnormal cell refuses to die. Hormonal changes Notable among these are changes in the female hormone levels estrogen. Excess…