Pharmacology Block D Lecture 2

Front 1

Whats the most significant driver of cardiovascular disease of todays growing population

Back 1

HBP

Front 2

Whats the primary prevention

Back 2

Reduce formation and rate of progression in coronary and peripheral atherosclerosis

Prevention of coronary events and strokes in apparently healthy persons at risk, particularly middle ages and elderly

Prevention of heart attacks, strokes in persons with established atherosclerosis

Front 3

Whats the two main bessels that the liver receives blood from

Back 3

Hepatic artery and the portal vein

Front 4

What does the hepatic artery do

Back 4

Supplies 25% of the total bloody flow and provides most the oxygen requirement

Front 5

What does the portal vein do

Back 5

Drains most of the gastrointestinal tract. Supplies 75% blood flow and transports the most recently absorbed material from intestines to the liver

Front 6

Whats the livers function

Back 6

Major role in protein, carbohydrate and lipid homeostasis, Stores glycogen, vitamins and iron

Extensive reticuloendothelial system for the synthesis and breakdown of rbc

Metabolise detoxify and excrete both endogenous and exogenous compounds

Front 7

What is HDL cholesterol

Back 7

Good combination of lipid and protein

Front 8

What is LDL cholesterol

Back 8

Implicated in athersclerosis

Front 9

What is cholesterol

Back 9

Waxy like substance

Steroid alcohol

Found in all cells of the body

Front 10

How is cholesterol synthesised

Back 10

Primarily in the liver

Occurs in cytoplasm and ER

Front 11

In the cholesterol synthesis whats rate limiting

Back 11

HMG-CoA reductase reaction

Front 12

Whats the first biproduct of cholesterol synthesis

Back 12

Mevalonic acid

Front 13

Whats the functions of cholesterol

Back 13

Cell membranes, sex hormones, hormones produced by adrenal glands, production of bile acids, vitamin D

Front 14

What are some types of lipid

Back 14

Chylomicrons, very low density lipoproteins(VLDL) intermediate-density lipoproteins (IDL), low density lipoproteins(LDL) and high density lipoproteins(HDL)

Front 15

Why does cholesterol transport in the circulatory system within lipoproteins

Back 15

Because its insoluble in the blood

Front 16

Lower the density the more what

Back 16

More fat

Front 17

HDL has the greatest amount of what

Back 17

Acid cholesterol

Front 18

What do chylomicrons carry

Back 18

Triglycerides(fat) from the intestines to the liver to skeletal muscle and to adipose tissue

Front 19

Whats the 6 major classes of apolipoproteins

Back 19

A B C D E and H

Front 20

ApoA-1 site of synthesis and function

Back 20

Liver, intestine

Structural in HDL; reverse cholesterol transport

Front 21

ApoA-V site of synthesis and function

Back 21

Modulates triglyceride incorporation into hepatic VDL

Front 22

ApoB-100 site of synthesis and function

Back 22

Liver

Structural protein of VLDL, IDL, LDL

Front 23

ApoB-48 site of synthesis and functions

Back 23

Intestine

Structural protein of chylomicrons

Front 24

ApoE site of synthesis and functions

Back 24

Liver brain skin gonads spleen

Structual in HDL; reverse cholesterol transport