What is cholesterol ?
Cholesterol is a fatty substance (lipid) that has a waxy appearance and found in the body cells of humans and animals, particularly the brain, kidneys, and liver. High amounts of cholesterol in our diets and blood can be viewed negatively because it is associated with coronary heart disease. 1 However, it is important to recognize that our bodies need cholesterol in many different ways.
Cholesterol is a member of a large group of substances called steroid, which include vitamin D. Cholesterol is an essential component of cell membrane, brain and nerve cells, and bile, which helps the body absorb fats and fat soluble vitamins. The body uses cholesterol to make vit.D and various hormones, such as estrogen, testosterone, …show more content…
Plasma lipids consist of triacylglycerols (16%), phospholipids (30%), cholesterol (14%), cholesterol ester (36%) and fatty acids free (4%). Lipids are transported in plasma lipoproteins (Figure 3). Four major classes of lipoproteins important are: chylomicrons, VLDL, LDL and HDL. Chylomicrons transport the lipids produced from digestion andabsorption; VLDL triacylglycerol transport from the heart; LDL channel cholesterol to the tissues, and HDL carries cholesterol to the tissues and return it to the liver to be excreted in a process known as reverse cholesterol transport (reverse cholesterol transport)
(Murray et al. 2003).
University of Northern Sumatra
Figure 3. cholesterol transport between various networks
2.1.3. Factors Affecting Plasma Cholesterol Concentration.
Some factors that may affect plasma concentrations are: Consumption of cholesterol which serves as the intrinsic feedback control, diet high in saturated fat, unsaturated fat diet will suppress concentration plasma cholesterol, deficiency of insulin or a steroid hormone would increase blood cholesterol concentrations while the excess steroid hormones will lowers plasma cholesterol concentrations (Guyton and Hall, 2006)
The process of cholesterol synthesis (image 2) consists of five main stages (King,
2010), among others:
1. Changing Acetyl CoA into
Cholesterol is a fatty substance (lipid) that has a waxy appearance and found in the body cells of humans and animals, particularly the brain, kidneys, and liver. High amounts of cholesterol in our diets and blood can be viewed negatively because it is associated with coronary heart disease. 1 However, it is important to recognize that our bodies need cholesterol in many different ways.
Cholesterol is a member of a large group of substances called steroid, which include vitamin D. Cholesterol is an essential component of cell membrane, brain and nerve cells, and bile, which helps the body absorb fats and fat soluble vitamins. The body uses cholesterol to make vit.D and various hormones, such as estrogen, testosterone, …show more content…
Plasma lipids consist of triacylglycerols (16%), phospholipids (30%), cholesterol (14%), cholesterol ester (36%) and fatty acids free (4%). Lipids are transported in plasma lipoproteins (Figure 3). Four major classes of lipoproteins important are: chylomicrons, VLDL, LDL and HDL. Chylomicrons transport the lipids produced from digestion andabsorption; VLDL triacylglycerol transport from the heart; LDL channel cholesterol to the tissues, and HDL carries cholesterol to the tissues and return it to the liver to be excreted in a process known as reverse cholesterol transport (reverse cholesterol transport)
(Murray et al. 2003).
University of Northern Sumatra
Figure 3. cholesterol transport between various networks
2.1.3. Factors Affecting Plasma Cholesterol Concentration.
Some factors that may affect plasma concentrations are: Consumption of cholesterol which serves as the intrinsic feedback control, diet high in saturated fat, unsaturated fat diet will suppress concentration plasma cholesterol, deficiency of insulin or a steroid hormone would increase blood cholesterol concentrations while the excess steroid hormones will lowers plasma cholesterol concentrations (Guyton and Hall, 2006)
The process of cholesterol synthesis (image 2) consists of five main stages (King,
2010), among others:
1. Changing Acetyl CoA into