Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
What is the structure of adrenoceptors |
3 Intracellular loops 7 transmembrane proteins NH2 group COOH group |
|
|
|
What is the enzyme called that cause the activation of an effector enzyme |
Adenylyl cyclase |
|
|
|
What does the beta 1/2 receptor couple to |
Gs |
|
|
|
What happens after Gs receptor activation result in |
Stimulates adenylyl cyclase to stimulate the formation of the second messenger cAMP |
|
|
|
What does cAMP activate |
Protein kinase A |
|
|
|
What does PKA activation lead to |
Change in cell function by phosphorylation of the next downstream intermediate |
|
|
|
What are beta 1 receptors linked to in the heart |
Linked to Gs |
|
|
|
What does linkage of Gs result in |
Increase cAMP and activates PKA |
|
|
|
What does alpha 1 couple to |
Gq |
|
|
|
What does the linkage of alpha 1 to Gq lead to |
Activation of this pathway causes stimulation of phospholipase C to generate two important second messengers |
|
|
|
What second messengers are generated from activation of the alpha 1 Gq pathway |
IP3 DAG |
|
|
|
What does IP3 cause |
Causes the release of Ca2+ from an Intracellular stores called ER |
|
|
|
What does smooth muscle activation of alpha 2 cause |
Contraction |
|
|
|
What is alpha 2 linked to |
Hi/Go |
|
|
|
What does the activation of the alpha 2 pathway result in |
Activation of Ca2+ channels to increase Ca2+ influx |
|
|
|
Which one of the following terms is not used to deceive adrenoceptors |
A. GPCR B. Heptahelical receptors C. 7 TMR receptors D. Ligand- hated ion channels E. GPCR |
D. Ligand gaged ion channels are of course a very different structure to GPCRs so adrenocpetors could never be called that |
