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26 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What are anti- hypertensives |
Medicines that reduce blood pressure |
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What are examples of anti hypertensives |
Propranolol Atenolol Bisoprolol Prazosin |
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What are anti angina agents |
Medicines that reduce Heart rate |
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What are examples of anti angina drugs |
Propranolol Atenolol |
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What are anti asthmatic drugs |
Medicines which widen the airways |
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What drugs are anti asthmatic |
Salbutamol Salmeterol |
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What is benign prostatic hypertrophy |
Medicines which relax and widen |
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What are examples of benign prostatic hypertrophy |
Doxazosin Tamsulosin |
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What are the classes of adrenoceptors |
Alpha and beta |
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What are the classes of alpha adrenocpetors |
Alpha 1 and alpha 2 |
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What are the classes of beta adrenoceptors |
Beta 1, beta 2, beta 3 |
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What are the effects of alpha adrenoceptors |
Vasoconstriction Dilation of pupil Contraction of uterus and ureters Relaxation of intestinal movements |
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What are the effects of beta adrenoceptors |
Vasodilation Stimulation of heart Relaxation of uterus |
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What is are the steps of alpha adrenoceptors |
Adrenaline> noradrenaline> alpha-meNA> alpha- meAdr> isoprenaline |
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What is are the steps of beta adrenoceptors |
Isoprenaline> adrenaline> alpha- meAdr> alpha- meNAr- noradrenaline |
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What does each arrow mean in terms of potency in the adrenoceptors in the alpha and beta pathway |
Each arrow is about 10-fold difference in potency so noradrenaline is 1000 times more potent than nor adrenaline |
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What is the rank order of beta receptors |
Isoprenaline>adrenaline> noradrenaline Therefore, isoprenaline is 100 times more potent then noradrenaline |
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What is the rank order of potency for alpha receptors |
Noradrenaline> adrenaline> isoprenaline |
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What one of the following drugs blocks neuronal uptake of noradrenaline |
A. Dopamine B. Guanethidine C. Cocaine D. Tyrosine L-DOPA |
Cocaine- uptake of 1 inhibitor |
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What are examples of alpha antagonists |
Ergotoxine Phentolamine Phenoxybenzamine |
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What are examples of beta antagonists |
Propranolol |
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How does beta 1 effect the heart tissue |
Increases force and rate of contraction |
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How does beta 2 affect the heart |
No major effect |
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How does beta 1 effect the smooth muscle tissue |
Decrease intestinal motility |
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What does beta 2 do to smooth muscle tissue |
Vasodilation Bronchodilaton Relaxation of uterus |
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What happens when noradrenaline is released from nerves |
It activates alpha 1 receptors post synaptically but at the same time stimulates the alpha 2 receptors to reduce NA release from the nerve terminal |
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