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51 Cards in this Set
- Front
- Back
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Herpes -> HSV-2
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Produces small vesicles and shallow ulcers that can involve the vulva, cervix, vagina, etc
MNGC's with eosinophilic intranuclear inclusions |
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Herpes Simplex Virus 2
Seen in males as ulcers |
What causes this?
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Herpes
MNGC's with viral inclusions in the nucleus |
What is this?
Describe what you see |
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HPV:
-Sexually transmitted __1__ virus -virus is located in the __2__ of affected cells -affected cells are called __3__ |
1. DNA
2. nucleus 3. Koilocytes |
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What is HPV associated with an increased risk of?
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Dysplasia
Carcinoma |
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What 2 ways does HPV stimulate the proliferation of Squamous epithelium?
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Exphytic = condyloma
Flat |
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Condylomata acuminata
HPV |
What is this called?
What is the cause? |
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Condyloma caused by HPV
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What is this showing?
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Koilocytes
HPV |
What are these cells called?
What causes them? |
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Pruritic vaginitis with a white discharge and a fiery red mucosa
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Candida
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Candidiasis
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What is this?
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What are 4 risk factors for Candidiasis?
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1. Diabetes
2. Broad-spectrum Antibiotics 3. Oral Contraceptives 4. Pregnancy |
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Wet mount of Candida
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What is this?
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Tuberculosis
Non-caseating granulomas in histology |
What is the cause of this?
How would your suspicion be confirmed? |
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Describe the pathophysiology of Bartholin's Gland Cyst
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Duct obstruction that leads to cyst formation -> edema and swelling
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What is the most common cause of Bartholin's Gland cyst?
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N. gonorrhoeae
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Bartholins Gland cyst
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What is shown at the right?
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-Abnormal growth of the Vulvar skin with white plaques and skin atrophy
-Histologically there is Hyperkeratosis, loss of Rete Ridges, an Acellular Zone, and Chronic inflammation |
Lichen Sclerosus
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Lichen Sclerosus
Itching or Painful sex |
What is this called?
How can it present clinically? |
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Lichen Sclerosus
-Hyperkeratosis -Loss of Rete ridges = undulation between dermis and epidermis -Acellular zone -Chronic Inflammation |
What is this?
How do you know? |
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Squamous Hyperplasia
- thickened epithelium - hyperkeratosis - epidermal dipping |
What is this and how do you know?
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Is a spectrum of neoplastic changes in the vulva, ranging from koilocytic changes to mild/moderate/severe dysplasia to Carcinoma in situ
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Vulvar Intraepithelial Neoplasia
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What is Vulvar Intraepithelial Neoplasia associated with?
What is it a precursor of? |
HPV 16, 6, 11
Squamous Cell Carcinoma |
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What is the most common cancer of the Vulva?
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Squamous Cell Carcinoma
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What are the 3 gross appearances Squamous Cell Carcinoma of the Vulva can be?
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1. Exophytic (2/3)
2. Ulcerative 3. Endophytic |
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Squamous Cell Carcinoma of the Vulva that has ulcerated through
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What is the pic showing?
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Squamous Cell Carcinoma of the Vulva that is invading the Stroma
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What is this picture showing?
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Anaplasia in Vulvar Squamous Cell Carcinoma
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What is this picture showing?
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Blood vessel filled with tumor = radical surgery is not enough -> need chemo or radiation as well
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What is this picture showing?
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How can Squamous Cell Carcinoma of the Vulva present clinically?
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1. Pruritis
2. Bleeding 3. Infection 4. Ulcer 5. Mass |
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Where do Squamous Cell Carcinomas of the Vulva metastasize to?
What is the survival rate for this cancer? |
Inguinal and Femoral Lymph Nodes
90% |
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Verrucous Carcinoma = Giant Condyloma
HPV 6 Squamous Cell Carcinoma Good -> invades locally |
What is this called?
What is the cause? What is it a variant of? What is the prognosis? |
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1. Verrucous Carcinoma
-finger-like projections at bottom 2. HPV 6 |
1. What is this?
2. What is most commonly associated with causing this? |
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Red, moist lesion on the labia majora
Often crusts over |
Extramammary Paget's Disease
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Extramammary Paget's Disease
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What is this?
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Extramammary Paget's Disease
Adenocarcinoma cells |
What is this?
What type of cells are they? |
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Melanoma
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What is this?
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Melanoma
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What is this?
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Replacement of the Squamous epithelium in the Vagina with Glandular Epithelium
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Vaginal Adenosis
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What is Vaginal Adenosis most commonly the result of?
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Prenatal DES exposure
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Describe the pathophysiology of Vaginal Adenosis (Vulvar Vaginosis)
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DES inhibits Mullerian differentiation -> see remnants of Mullerian glands -> Adenocarcinoma
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Vaginal Adenosis
DES exposure |
From a vaginal biopsy:
What is it? What is it the result of? |
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Vaginal Adenosis (Vulvar Vaginosis)
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What is this?
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Clear cell adenocarcinoma
DES exposure |
From a vaginal biopsy:
What is it? What causes it? |
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What is the most common cancer of the vagina?
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Squamous Cell carcinoma
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Vaginal Squamous Cell Carcinoma
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What is this?
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Polypoid mass resembling a "bunch of grapes" on vaginal exam in a 3 year old girl
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Embryonal Rhabdomyosarcoma = Sarcoma Botryoides
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Embryonal Rhabdomyosarcoma (Sarcoma Botyroides)
Child < 4 years old |
What is this?
How old of a person would have this? |
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Replacement of normal squamous epithelium by a glandular epithelium. History of DES exposure in the early prenatal life
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VULVAR VAGINOSIS
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A rare vulvar neoplasm in which malignant, large, pale vacuolated cells are found scattered throughout the epidermis. Wide local excision is usually curative
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Extramammary Paget's Disease
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A variant of well differentiated squamous cell carcinoma that presents as a large fungating mass resembling a giant condyloma. HPV type 6 is commonly identified in this tumor. The tumor invades locally and typically does not metastasize. Local surgical excision is the treatment of choice
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Verrucous carcinoma
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