Pathology - S2B1 - Male Gu 3

Front 1

What is the difference in treatment in Seminomas and Nonseminomatous Germ-cell tumors (NSGCT)?

Back 1

Seminomas are RADIOSENTITIVE

Front 2

What is the most common site of Metastases of Seminomas?

Back 2

Para-aortic lymph nodes

Front 3

Seminoma

Back 3

A 30 year old man noticed painless enlargement of the left testicle and after 3 months decided to consult his family physician. The physician palpated the testes and found that the left testicles is enlarged and irregularly nodular and firm. He referred him to a urologist. AFP and hCG were normal

Front 4

Seminoma
-tumor cells are arranged in lobules surrounded by fibrous strands and infiltrated with lymphocytes

Back 4

What is this?
How do you know?

Front 5

Intratubular Testicular Germ Cell Neoplasia = carcinoma in situ

Back 5

What is this?

Front 6

Teratoma
- keratin pearls
- glands
-neural tissue

Back 6

What cancer is this?
How do you know?

Front 7

Choriocarcinoma cells
- bulky masses with Hemorrhage and necrosis

Back 7

What germ cell tumor is this?
What is the characteristic microscopic feature?

Front 8

Yolk Sac
Schiller-Duval Bodies
AFP

Back 8

What Germ Cell Tumor?
How do you know?
What do they secrete (tumor marker)?

Front 9

Leydig cell tumor

90% are usually benign

*androgens secreted from Leydig tumor cells caused precocious puberty

Back 9

8 year old boy bragged to his friend that his penis has grown during the summer vacation and that he has pubic hair. Had elevated blood androgens.
-What testicular cancer?
-Is it most likely to be benign or malignant?

Front 10

Leydig Cell tumor
- Reinke crystalloids
- round nuclei with eosinophilic cytoplasm

Back 10

What type of tumor is this?

What are the characteristics of the histology?

Front 11

Yolk Sac Tumor
- 2 year old
- Schiller-duval bodies

Back 11

A 2 year old had a tumor mass. This is the histology of the mass.

Front 12

Yolk Sac tumor
-Schiller-Duval bodies

Back 12

What testicular tumor?

Front 13

Mumps
- Meningitis
- Orchitis = Seminiferous tubule with inflammation
- Parotitis

Back 13

A 3 year old boy developed fever, swelling on both sides of his face. The left testicle was enlarged and sensitive to touching.

Front 14

A 70 year old man noticed that his right testis is enlarged and slightly painful and sensitive to palpation

What is the MOST LIKELY tumor?

Back 14

Metastases from a different site
- Malignant Lymphoma

Front 15

1. Male infertility
2. FSH (b/c loss inhibin made from Sertoli cells)
3. loss of Seminiferous tubules and decreased Testosterone
4. Orchitis, ischemia, toxic injury

Back 15

1. What is this condition?
2. What would be elevated?
3. What would cause a decreased sperm count?
4. What are possible causes?

Front 16

1. Leygid Cell tumor
2. Secrete hormones
- Androgen = macrogenitosomia
- Estrogen = Gynecomastia

Back 16

A 50 year old man noticed that his breast have enlarged during the last 6 months. He also noticed slight scrotal discomfort. Physical examination revealed an irregularly enlarge slightly nodular left testicle.
1. What is the tumor?
2. What is the cause of the symptoms?

Front 17

Syphillis = Treponema pallidum

Back 17

What would be the cause of these 2 symptoms?

Front 18

Systemic Vasculitis involving small blood vessels in many organs:
1. Recurrent ulcers
-mouth
-penis/scrotum that are painful
-vulva/vagina
2. Skin purpura/ulcerations
3. Arthritis

Back 18

Behcet Syndrome

Front 19

Neisseria gonorrhoea

Back 19

A 28 year old man came back from a weekend in Baltimore and noticed a yellow discharge from his penis, associated with burning pain

Front 20

N. gonorhoea inside neutrophils
- diplococci

Back 20

Specimen taken from a urethral discharge

What is the agent?

Front 21

What are the 3 most common microbes causing Urethritis?

Back 21

1. Chlamydia trachomatis
2. N. gonorrhoea
3. Ureaplasma urealyticum

Front 22

Non-infectios Urethritis of unknown etiology preceded by GI or GU infections

Clinical Triad:
- Urethritis
- Conjunctivitis
- Arthritis of weight carrying joints

Back 22

Reiter Syndrome

Front 23

Fibromatosis of the penis in adults
- curvature of erect penis
- pain on erection
- painful intercourse

Back 23

Peyronie disease

Front 24

What part of the penis has fibrosis in Peyronie disease?

Back 24

Tunica Albuginea

Front 25

Indwelling Catheter

Back 25

A 60 year old man underwent coronary artery bypass surgery. In the first urine that he voided on his own he noticed blood.

What is this most likely due to?

Front 26

Transitional Cell Carcinoma of the bladder

Smoking

Back 26

What type of cancer is this?

What is the greatest risk factor?

Front 27

Benign Prostatic Hyperplasia
- median lobe of prostate has formed a valve
- trabeculae are on the bladder wall

Back 27

Describe all the findings you see here

Front 28

Benign prostatic hyperplasia
- trabeculae
- stones
- diverticulum

Back 28

What is the cause of all this?

Front 29

Prostate cancer

Back 29

What is this?

Front 30

Prostate Cancer

Adenocarcinoma

Back 30

What cancer is this?

What histological cancer is it?

Front 31

Benign Prostatic Hyperplasia

Back 31

A 62 year old man had a yearly check-up. The only abnormality was elevation of PSA in the blood. Biopsy showed this. What is the diagnosis?

Front 32

Embryonal Carcinoma Cells in NSGCT

Back 32

What is this?

Front 33

-

Back 33

-

Front 34

Mumps

Back 34

What likely caused this?

Front 35

Rectum
Urinary Bladder
Prostate

Back 35

This is metastatic testicular cancer. From where did it most likely originate?

Front 36

Metastatic Testicular Adenocarcinoma = came from somewhere else

Back 36

What kind of tumor is this?

Front 37

Papillary Trasitional cell of the Urinary Bladder

Back 37

What kind of tumor is this?