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31 Cards in this Set
- Front
- Back
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What is the ddx for diffuse increase in bone density
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osteoblastic mets
pagets disease AND 5 OSIS's myelosclerosis fluorosis mastocytosis osteopetrosis hypervitaminosis D |
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What is mastocytosis?
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rare condition in which too many mast cells (cells which release histamine) are made
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What is osteopetrosis
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is an extremely rare inherited disorder whereby the bones harden, becoming denser, but these patients are at increased risk of fracture
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What is myelofibrosis?
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is a disorder of the bone marrow. It is currently classified as a myeloproliferative disease in which the proliferation of an abnormal type of bone marrow stem cell results in fibrosis, or the replacement of the marrow with collagenous connective tissue fibers
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What is a cause of myelofibrosis which may result in increased density of bones
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sickle cell anemia
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What is the DDX for diffuse decrease in bone density
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osteoporosis
osteomalacia hyperparathyroidism paralysis osteogenic imperfecta |
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Does multiple myeloma cause osteoporosis
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yes
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What medication may lead to osteoporosis
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corticosteroids
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What is the DDX for a focal sclerotic bone lesion
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osteosarcoma
blastic mets lymphoma pagets disease bone island healed fractures bone infarcts osteoid osteoma |
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Does metastic prostate cancer cause blastic mets
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yes
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What is the ddx for a focal lytic lesion
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myeloma
lytic mets eosinophilic granuloma brown tumor (hyperparathyoid) |
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What is the DDX for round cell lesion which produce a permeative pattern
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ewings sarcoma
osteomyelitis multiple myeloma lymphoma/leukemia neuroblastoma |
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What is the DDX for expansile lytic lesion of bone
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multiple myeloma (plasmacytoma)
mets ABC fibrous dysplasia brown tumor enchondroma |
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What is the DDX for an expansile rib lesiona
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plasmacytoma (in pt with multiple myeloma)
mets chondrosarcoma fibrous dysplasia enchondroma eosinophilic granuloma neurofibromatosis |
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What is a syndrome that 3% of people who have fibrous dysplasia are diagnosed with
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mccune albright
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What percent of primary bone tumors are chondrosarcomas
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25%
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What is the DDX for a soap bubbly lesion
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mets
giant cell tumor plasmacytoma chondrocarcoma |
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What type of lesion does kidney cancer cause
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lytic
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What is the DDX for lesions associated with soft tissue masses
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MM
mets osteo priomary malignancy such as osteosarcoma |
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What is the DDX for sclerotic cortical lesion of bone
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osteiod osteoma
brodies abscess (from chronic osteomyelitis healing stress fracture |
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What is the DDX for a short fourth metacarpal
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isolated anomaly
turners syndome psuedohypoparathyroidism |
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What is clinodactyly
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a bend or curvature of the fifth fingers (the "little fingers") toward the adjacent fourth fingers.
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What is the DDX for clinodactyly
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downs syndrome
otopalatodigital syndrome cornelia de lange syndrome |
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What causes clinodactyly in otopalatodigital syndrome
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A very rare syndrome characterized a variety of abnormalities including skeletal anomalies, distinctive face and cleft palate
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What is the ddx of polydactyly
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isolated anomaly
ellis van creveld syndrome carpenters syndrome |
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What is the ddx of syndactyly
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carpenters syndrome
aperts sydrome polands sydrome |
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What is syndactyly
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this is when two or more fingers are fused
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What is aperts syndrome
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it is a syndrome that involves malformation of the skull, hands and feet and is associated with syndactyly
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What is polands syndrome
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rare birth defect characterized by underdevelopment or absence of the chest muscle (pectoralis) on one side of the body and (but not always) webbing of the fingers (
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What is carpenter syndrome
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autosomal recessive congenital disorder characterized by craniofacial malformations, obesity, and syndactyly or polydactyly
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What is the ddx for erosion of the distal clavicle
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rheumatoid arthritis
hyperparathyroidism scleroderma |
