Mkgrady8 Host2 Mycoplasma And Ureaplasma

Front 1

the family mycoplasmatacea is composed of

Back 1

mycoplasma (M pneumonia (Eaton agent), M hominis, and M gentalium) and Ureaplasma (U urealyticum

Front 2

mycoplasmatacea characteristics

Back 2

smallest free living bac; T strains because they are tiny; lack cell wall and have cholesterol in their membranes (so not gram positive or gram negative); complex media needed for growth (fried egg colonies; marked pleomorphism; resistant to beta lactam antibiotics; cultures have fried egg appearance; extracellular

Front 3

mycoplasmatacea pathogenesis (how does it invade)

Back 3

adherence protein P1 (M paneumoniae); toxic metabolic products (hydrogen peroxide, superoxide, inhibits host catalase activity); immune system activation (M pneumoniae is a superantigen so a lot of host cytokines are release in response to it and this causes most of the damage that we see in the host)

Front 4

mycoplasmatacea diagnosis (how do you make it)

Back 4

microscopy; culture (insensitive and long incubation time) but can grow on Eaton's agar; antigen detection (M. pneumoniae, insensitive, cross reactions); CXR often looks worse than symptoms suggest (M pneumoniae called walking pneumonia because of this)

Front 5

mycoplasma pneumoniae epidemiology (where is it found, what is the reservoir, how is it transmitted, who does it effect)

Back 5

worldwide; only reservoir is humans; transmission through aerosolized droplets and close contact; disease of childhood

Front 6

mycoplasma pneumoniae pathogenesis (course of symptoms)

Back 6

incubation 2-3 weeks and most people are asymtomatic, fight it off, and never knew they had it; (if they do have symptoms) initial symtoms (fever, malaise, headache, pharyngitis, cough, tracheobronchitis); late symptoms (pneumonia, neurologic, pericarditis, hemolytic anemia, arthritis, mucocutaneous lesions); recovery is very slow; death is very unlikely unless in an immunocompromised pt

Front 7

Mycoplasma pneumonia diagnosis (how do you make it) and treatment

Back 7

clinical manifestations, serology (acute and convalescence sera, tracheobronchitis), cold agglutinins (erythrocytes, other diseases), PCR (he ended up saying that non of these are really all that helpful)(card says use cold hemagglutination, culture (although it takes a couple weeks to grow), and serology); treatment= most pts are self limiting so if the symptoms aren't that bad then don't treat, no vaccine available

Front 8

mycoplasma hominis causes what

Back 8

pyelenonephritis, pelvic inflammatory disease, post partum fever, systemic infections; diagnose with a culture

Front 9

mycoplasma gentalium and ureaplasma urealyticus cause what

Back 9

non gonicoccal urethritis; newborns= penurmonia, premature delivery; diagnose with a culture; U urealyticum is IDd by production of urease and because their colonies are NOT fried egg but just a dark compact colony

Front 10

what are the common causes of atypical pneumonia

Back 10

mycoplasma, legionella, chlamydia, and viruses

Front 11

what are the most common causes of pneumonia in adults (18-40)?

Back 11

mycoplasma, C. pneumonia, S. pneumoniae