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19 Cards in this Set
- Front
- Back
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Maternal screen testing to
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identify potential birth defects or serious chromosomal abnormalities
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The incidence of Trisomy 18 and 21 increase with
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maternal age
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At age 25, the risk of having a baby with trisomy 21?
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1 in 1300
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At age 35, the risk of having a baby with trisomy 21?
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1 in 365
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At age 45, the risk of having a baby with trisomy 21?
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1 in 30
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Wheen is maternal screening usually done?
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2nd trimester (14-20 weeks)
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Estriol snf hCG are produced
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by the placenta
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What does the quadruple test measure?
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hCG, AFP, estriol, and inhibin A
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What does the fully integrated screen test measure?
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total and beta hCG, AFP, estriol, fetal nuchal translucency, and PAPP-A
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Which test is most common?
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triple test
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What tests can be performed in the first trimester?
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fetal nuchal translucency, beta subunit of hCG, PAPP-A
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What does decreased PAPP-A indicate?
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increased risk of a stillborn
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What are the results of the triple test in women carrying Trisomy 21 babies?
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25% lower estriol and AFP and 2x increase in hCG
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What is used to calculate the risk for chromosomal abnormalities
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maternal weight, MoM, and fetal age
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Secreted by the granulosa cells in overies and inhibits production of FSH?
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Inhibin A
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In Trisomy 21, Inhibin A
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twice as high
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Increased Inhibin A also can indicate
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an increased risk of spontaneous abortions
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PAPP-A is produced
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placenta and endometrium
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Low levels of PAPP-A at 8-14 weeks indicates
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increased risk of intrauterine growth restrictions, trisomy 21, premature delviery, preeclampsia, and stillbirth
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