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21 Cards in this Set
- Front
- Back
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What diseases do the MHC allele DR2 associate with? |
Goodpasture Allergy (hay fever) Multiple Sclerosis Narcolepsy |
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What diseases do the MHC allele DR3 associate with? |
Sjogren Diabetes 1 multiple Sclerosis Graves Lupus Hepatitis Myasthenia Gravis |
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What diseases do the MHC allele DR4 associate with? |
Pemphigus Vulgaris Rheumatoid Arthritis Diabetes Mellitus I |
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What diseases do the MHC allele DR5 associate with? |
Pernicious Anemia Hashimoto Thyroiditis Juvenile Rheumatoid |
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What diseases do the MHC allele DR7 associate with? |
steroid responsive syndrome` |
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What diseases do the MHC allele HLA-B27 associate with? |
ankylosing spondylitis inflammatory bowel DZ Reiter DZ |
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What type of Hypersensitivity does Pernicious Anemia belong to? |
Type II |
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What cause Pernicious Anemia? |
body can't absorb Vitamin B12 from the GI tract Ab attack cells that makes Intrinsic factor or Intrinsic factor itself. |
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Thrombocytopenic Purpura |
Type II Ab attached to platelet membrane splenic sequestration phagocytosis by mono nuclear macrophages sxs: easy bruising , petechiae |
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Pemphigus Vulgaris |
Ab against desmogelin 1 and desmoglein 3
lost of cohesion between keratinocytes in epidermis |
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What is the difference between diffused Scleroderma and systematic Scleroderma? |
Scleroderma: topoisomerase (Scl-70) anticentromere antibodies. systematic: tissue fibrosis diffused: renal crisis and failure, pulmonary myocardialfibrosis |
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What is distinctive about drug-induced lupus |
high [auto antibodies] titers to histones |
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What is central tolerance? |
immature lymphocytes specific for self antigen 1. deletion of B lymphocytes 2. change their specificity 3. develop into regulatory cells |
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in order to differentiate into regulatory T cell in the thymus what is needed? |
Foxp3 (transcription factor) IL-2 |
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How does regulatory T cell do its job? |
production of cytokines: IL-10: reduce production of IL-2 IL-5 and TNF-α TGFβ : blocks T-cellcytokine production, cell division, and killing ability |
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What is Epitoope spreading? |
exposure of sequestered autoantigen as a result of damange to cell caused by viral infection which is stimulate autoreactive T cell |
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What type of MHC molecules influence activatio of regulator T cells? |
Class II MHC molecules |
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What is peripheral T cell tolerance mediated by? |
induction of anergy or apoptosis after interaction of T cell with self-antigen |
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Polymorphisms in what gene is associated with autoimmue dz in humans? |
CTLA4 gene an inhibitory receptor of CD28 family recog B7 costimulator that bind to CD28 initating anergy |
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What does Superantigens do? |
they cause non-specific activation of T cell by DIRECT stimulation resulting in polyclonal T cell activation and massive cytokine release |
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Where are the locations that Superantigens exert its effect? |
bind first to MHC II then goes to Tcell receptor by a specific variable beta motif |
