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17 Cards in this Set
- Front
- Back
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When was HCV identified? |
1989 |
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What is the characteristic of the HCV genome? |
positive ssDNA 9.5kB |
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What family is HCV from? |
Flaviviridae |
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What organ/cell does the HCV infect? |
lung/hepatocytes |
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May are the causes of the hepatitus virus? |
virus drugs secondary manifestation of systematic illnesses |
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What are the two phases of Hepatitis virus infection? |
1. nausea, liver enlargement, anorexia 2. icteric phase - jaundice (yellow discolouration of eyes and skin due to bilirubin in blood) |
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What is cirrhosis? |
- Scarring of liver - formation of nodes on liver due to damaged tissues - loss of liver function |
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How is HCV identified? |
infect chimpanzees with HCV, screen cDNA expression, isolate HCV |
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What are the forms of transmission of HCV? |
50% intravenous drug use blood to blood contact vertical transmission occupational (nurses prick self with infected blood) |
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What is the main difference between HCV and other flaviviridaes viruses? |
Most flaviviridae virsus are transmitted via an anthropod vector. But most common transmission route for HCV is IDUs. |
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How many genotypes of HCV are there?
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6 genotypes |
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What are the most common HCV genotype in AUS? |
1a and 3a |
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How many structural genes are there in the HCV gene? what do these genes encode? |
3: core, E1 and E2. these genes encode for the capsid, E1 and E2 forms the glycoprotein. |
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What % of ppl infected with HCV will go on to lifelong infection/Cirrhosis? |
15-25% |
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What % of ppl infected with HCV willl make spontaneous recovery? |
15-45% |
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What are the factors that contribute to viral infection? |
host: old age, female, compromised immune system (HIV) virus viral load, viral quasispecies, co-infection? |
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What are the 2 methods of diagnosing HCV? |
1. EIA = enzyme immunoassay - screen for HCV antibodies 2. RT-PCR - screen for RNA genome |
