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52 Cards in this Set

  • Front
  • Back

Human body contains over

600 skeletal muscles (40-50% of total body weight)

3 major functions of Skeletal Muscles

Force production for locomotion and breathing, and for postural support, also heat production during cold stress.

Flexors

Decrease joint angle

Extensor

Increase joint angles

Epimysium

Surrounds entire muscle

Perimysium

Surrounds bundles of muscle fibers

Endomysium

Surrounds individual muscle fibers

Satellite cells

Play key role in muscle growth and repair

Myonuclear domain

Volume of cytoplasm surrounding each nucleus

More nuclei allows

Greater protein synthesis

Myofibrils

Contain contractile proteins such as actin (thin) and Mayosin (thick)

Sarcoplasm reticulum

Storage sites for calcium, terminal cisternae

Sarcomere

Includes z line, M line, h zone, A band, I band

Transverse tubules

Extend from sarcolema to sarcoplasmatic recticulum

Neuromuscular Junction

Junction between motor neuron and muscle fiber

Motor end plate

Pocket formed around motor neuron by sarcolemma

Neuromuscular cleft

Short gap between neuron and muscle fiber

Individual muscle fibers are composed of hundreds of threadlike protein filaments called

Myofibrils

Importance of myonuclear domain

single nucleus is responsible for the gene expression for its surrounding cytoplasm

Acetylcholine is

Neurotransmitter that stimulates the muscle fiber to depolarize, which is the signal to start the contractile processes

Process of muscular contraction can be best explained by what model ?

Sliding filament/ swinging cross-bridge model

Process of muscular contraction can be best explained by what model ?

Sliding filament/ swinging cross-bridge model

What does Sliding filament\ swinging cross bridge model proposes?

Muscle shortening occurs due to movement of the actin filament over the myosin filament

Excitation-contraction coupling refers to

Sequence of events in which nerve impulse (action potential) depolarizes the muscle fiber, leading to muscle shortening by cross-bridge cycling

The trigger to initiate muscle contraction is

Depolarization-induced release of calcium from the sarcoplasmic reticulum

Muscular contractions occurs via

The binding of the myosin cross-bridge to actin and the repeated cycling of myosin pulling on the actin molecule resulting in the shortening of the muscle fiber

Muscular contractions occurs via

The binding of the myosin cross-bridge to actin and the repeated cycling of myosin pulling on the actin molecule resulting in the shortening of the muscle fiber

Muscle relaxation occurs when

The motor neuron stops exciting the muscle fiber and calcium is pumped backed into the sarcoplasmic reticulum

Removal of calcium from the cytosol causes a position change in tropomyosin, which blocks the

Myosin cross-bridge binding site on the actin molecule

Muscle fatigue

Decline in muscle power output

Causes of exercise-induced muscle fatigue are complex and vary depending upon what?

Type of exercise performed

Muscle cramps

spasmodic and involuntary skeletal muscle contractions

Research indicates that many cases of exercise-associated muscle cramps occur due to

Abnormal spinal reflex activity that results in hyper active motor neurons

Human skeletal muscle fiber types are divided into three general classes of fibers, what are them ?

Type 1, Type IIx, Type lla

Type 1 fibers

Slow-twitch, slow oxidative fibers

Type 1 fibers

Slow-twitch, slow oxidative fibers

Type 11a fiber

Intermediate fibers, fast oxidative glycolytic fibers

Type 1 fibers

Slow-twitch, slow oxidative fibers

Type lla fiber

Intermediate fibers, fast oxidative glycolytic fibers

Type IIx fibers

Fast-twitch fibers, fast-glycolytic fibers

Biochemical properties of muscle fiber types

Oxidative capacity, type of myosin ATPase isoform, Abundance of contractile protein in the muscle fibers

Biochemical properties of muscle fiber types

Oxidative capacity, type of myosin ATPase isoform, Abundance of contractile protein in the muscle fibers

Contractile properties of Muscle fiber types

Maximal force production, speed of contraction (Vmax), maximal power output, muscle fiber efficiency

Successful power athletes (sprinters, power lifters) possess what type of fibers ?

Large percentage of fast muscle fibers, and therefore a low percentage of slow, type l fibers

Successful power athletes (sprinters, power lifters) possess what type of fibers ?

Large percentage of fast muscle fibers, and therefore a low percentage of slow, type l fibers

Endurance athletes posses what type of fibers

High percentage of slow muscle fibers and a low percentage of fast fibers

Isometric

Muscle exerts force without changing length

Dynamic (isotonic)

Concentric (muscle shortens during force production) eccentric ( muscle produces force but length increases)

The amount of force generated during muscular contraction is depending on what factors

1. Types and number of motor units 2. The initial muscle length 3. The nature of the motor units’ neural stimulation

Summation

The addition of muscle twitches

When the frequency of neural stimulation to a motor unit is increased

Individual contractions are fused in a sustained contraction called tetanus

When the frequency of neural stimulation to a motor unit is increased

Individual contractions are fused in a sustained contraction called tetanus