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5 Cards in this Set
- Front
- Back
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What five types of different forms of metabolism are there? |
-oxidation -reduction -Acetylation -Hydrolysis -Conjugation |
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What two phases of drug metabolism are there? |
-Phase I is Oxidation/reduction/Hydrolysis -Phase II is conjugation |
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What isoforms of CYP450 enzymes are there? |
-CYP1A2 -CYP3A -CYP2C9 -CYP2C19 -CYP2D6 |
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How does the cytochrome P450 system nomenclature work e.g. for CYP2D6? |
-CYP = cyctochrome P450 -2 = genetic family -D= genetic sub-family -6 = specific gene -nomenclature is genetically based , it has no functional implication |
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What is the effect of any drug with regards to its metabolism? |
-The route in which it is metabolised -Whether the drug or its metabolite is "active" -Whether its pathway is affected by the polymorphism -Whether there is the route compensated by other enzymes |
