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5 Cards in this Set

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What five types of different forms of metabolism are there?






What two phases of drug metabolism are there?

-Phase I is Oxidation/reduction/Hydrolysis

-Phase II is conjugation

What isoforms of CYP450 enzymes are there?






How does the cytochrome P450 system nomenclature work e.g. for CYP2D6?

-CYP = cyctochrome P450

-2 = genetic family

-D= genetic sub-family

-6 = specific gene

-nomenclature is genetically based , it has no functional implication

What is the effect of any drug with regards to its metabolism?

-The route in which it is metabolised

-Whether the drug or its metabolite is "active"

-Whether its pathway is affected by the polymorphism

-Whether there is the route compensated by other enzymes