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15 Cards in this Set
- Front
- Back
Define Anemia.
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Anemia is a reduction in the oxygen transport capacity of blood, usually as a result of a reduction below normal limits of the total circulating red cell mass.
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Name two things that are increased in MOST anemias.
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1. Erythropoietin Production
2. Erythropoiesis |
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In most anemias, erythropoietin production and erythropoiesis are increased. This causes ___ ___ ___.
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erythroid marrow hyperplasia
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What is extramedullary hematopoiesis?
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Extramedullary (outside the marrow) hematopoiesis may occur in organs such as the spleen and liver in severe anemias or when there is intrinsic disease in the marrow (e.g., myelofibrosis).
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What is erythropoiesis?
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The production of RBCs in the bone marrow.
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List the 3 primary causes of the anemias.
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1. Blood Loss
2. Increased Rate of RBC destruction. (Hemolytic Anemias ) 3. Impaired Red Cell Production. |
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What are the three features which characterize the Hemolytic Anemias?
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1. Premature destruction of Red Cells.
2. Accumulation of the products of hemoglobin catabolism (e.g., bilirubin). 3. Marked increase in erythropoiesis within the marrow and associated reticulocytosis. |
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With hemolytic anemia, the hemolysis may occur ___ or ___.
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intravascularly , extravascularly
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Intravascular hemolysis occurs when red cells are damaged by ___ or ___.
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mechanical injury (e.g., microangiopathic hemolytic anemia)
complement-mediated lysis (e.g., antibody-coated mismatched blood transfusion) |
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Intravascular hemolysis can be identified by 4 manifestations.
What are they? |
1. Hemoglobinemia and Hemoglobinuria
2. Hemosiderinuria 3. Jaundice (conjugated hyperbilirubinemia) 4. Reduction in serum haptoglobin (a protein that binds free hemoglobin). |
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The manifestations of extravascular hemolysis are similar to those of intravascular hemolysis except for the absence of ___ and ___.
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hemoglobinemia , hemoglobinuria
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What are the three predisposing factors leading to extravascular hemolysis?
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1. Injury to the red cell membrane.
2. Reduced deformability. 3. Opsonization. |
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Explain the major difference in the anemias caused by Acute Blood Loss, vs. those caused by Chronic Blood Loss.
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Acute Blood Loss- alterations reflect principally the loss of blood volume. After several days, the marrow compensates by an increase in reticulocytes.
Chronic Blood Loss- anemia usually results when iron reserves are depleted, giving rise to iron deficiency anemia. The marrow is active (erythropoiesis) as iron BECOMES AVAILABLE. |
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A practical working definition of anemia (BRS, Ch. 11) is a decrease in ___ count, ___, or ___.
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RBC, hemoglobin, hematocrit
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Extravascular Hemolysis occurs within the mononuclear phagocytic cells of the ___ and other organs.
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spleen
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