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171 Cards in this Set

  • Front
  • Back

What are 4 categories of hallucinogens?

Cholinergic hallucinogens, serotonergic or 5-HT like hallucinogens, methylated amphetamines (aka noradrenergic hallucinogens), and other/miscellaneous

What are some plant substance examples for cholinergic hallucinogens?

Atropine, Scopolamine (and Hyoscyamine), Arecoline, and Ibotenic Acid

Atropine can be extracted from which plant(s)?

Atropa Belladonna, Dautra Stramonium, and Mandragora Officinarum

Scopolamine & hyoscyamine can be extracted from which plant(s)?

Dautra Stramonium, Mandragora Officinarum, and Henbane

Arecoline can be extracted from which plant(s)?

Areca Nut

Ibotenic Acid can be extracted from which plant(s)?

Amanita Muscaria and Ibogaine

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Atropa Belladonna, aka nightshade: Cholinergic Antagonist Hallucinogen

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Dautra Stramonium, aka jimsonweed: Cholinergic Antagonist Hallucinogen

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Mandragora Officinarum, aka mandrake: Cholinergic Antagonist Hallucinogen


Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Henbane, aka hyoscyamus niger: Cholinergic Antagonist Hallucinogen

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Areca nut, aka betel nut: Cholinergic Agonist Hallucinogen

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist. 

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Amanita Muscaria, aka fly agaric mushroom: Cholinergic Agonist Hallucinogen

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist. 

Name the plant, any alternative name of the plant, and if it is an agonist of antagonist.

Ibogaine, no alternative name: Cholinergic Agonist Hallucinogen


Which plant made a Viking a 'berserker'?

Amanita Muscaria

What does the cholinergic agonist hallucinogen do/activate?

Stimulates primarily muscarinic cholinergic receptors which produces greater neural activity in the cholinergic nervous system which is a system critically involved with learning and memory.

T/F: The fly agaric mushroom produces "agitated raving" and feeling of invincibility.

True

What are 2 main psychoactive extracts from the Amanita Muscaria mushroom? How are they disposed of?

Ibotenic acid (which is metabolized to muscazone) and muscimole (doesn't metabolize into anything, jut excreted in urine). It is excreted in urine with a similar dose as the original one.

What are some side effects of cholinergic activation induced by Amanita?

Initialperiod of good humor and light euphoria (state of intense happiness) which leads to feelings of detachmentand unreality. Feelings ofincreased power, agitated raving, twitching and trembling of the limbs. Visions ofthe supernatural and illusions of grandeur including severalunpleasant physiological consequences. in addition, other side effects include markedlacrimation (tearing up), salivation and sweating, pinpoint pupils (can’t seein the dark), severe abdominal pains and painful diarrhea, coma, convulsions,and potentially death.

Which drug was used as a warfare agent?

Amanita Muscaria. Soldiers care kits in war zones to counteract the agent within a few seconds of attack.

How would you consume Ibogaine?

You chew the yellow roots of the plant

What happens when a hunter consumes a low dose of ibotenic acid?

Stimulantallows hunters to endure long treks and searches for food.

How long do the effects of ibotenic acid last?

Up to 30 hours

T/F: Ibogaine was once sold inFrance in the 1960s as an over the counter medication for fatigue.


True

Which drug triggered repressed memories?

Ibotenic acid. One of the effects includes the taker experiencing some mystical/meditative effects that triggers repressed memories.

When a heroin addict takes ibogiane recreationally, how is the experience described as?

Described as potentially healing; lead to the reputation of it curing heroin addiction

What is a 'street cure'?

Heroin addicts take ibogaine during treatment. No sufficient evidence that supports the claim but it is still used in modern treatment regardless.

What is the DEA schedule classification of Ibogaine?

Schedule IClassification: No currentlyaccepted medical use and a high potential for abuse. Schedule I drugs are themost dangerous drugs of all the drug schedules with potentially severepsychological or physical dependence.

What does the cholinergic antagonist hallucinogen do/activate?

Blocks muscarinic cholinergic receptors which produces deliriants/hallucinogens.

Atropa Belladonna is what kind of plant and is known as what 2 things?

Alkaloid plant known as deadly nightshade or love apples (because it was thought to be an aphrodisiac)

The Atropa Belladonna plant is part of what family?

Potato/tomato family

When was atropine first isolated and from what plant?

First isolated in 1830 from the Atropa Belladonna plant.

T/F: The Atropa Belladonna was named 'Atropa' for Atropos, the Fate that sees the past.

False. It was named after Atropos because this Fate cut the string of life. This is symbolism for poison.

T/F: The Atropa Belladonna was named 'Belladonna' because the ancient use of the plant was women instilling the juice of the nightshade berries on their eyes to dilate pupils (direct correlation with beauty).

True since belladonna is Italian for beauty.

Was atropine ever used in sexual activities?

Yes... yes it was.

What are some physiological side effects induced by atropine?

Rapid heartbeat, dilatedpupils, loss ofbalance and staggering, blurredvision, feelinglike one is suffocating, extremelydry throat, husky voice, flushing, palenessfollowed by a red rash, urineretention, constipation, pain, convulsionand uncontrollable body movements.


What are some psychological side effects induced by atropine?

Produces adream like state in which the user experiences pleasing hallucinations, vividand erotic dreams, and a sense of weightlessness. Upon awakening, the user may have some difficulty distinguishing reality from hallucination which cause amnesia.

How was atropine linked to the witch hunt?

Women thought the drug is an aphrodisiac so they would absorb the drug vaginally and feel so weightless that they would yell “I'm flying!” This was later used as empirical evidence of witchcraft.

What would happen if you overdose on atropine?

Your hallucinations would be terrifyingly traumatic and you would die.

Other than jimsonweed, what else is Datura stramonium known as?

Jamestow weed, thorn apple, loco weed, devil's weed, and stinkweed.

T/F: Scopolamine and atropine are known for producing feelings of nausea and dizziness.

False. Scopolamine and atropine are known for producing feelings of weightlessness and a sensation of flying.

What other drug, other than atropine, was linked to witchcraft?

Scopolamine which is an extract from Datura stramonium (as well as atropine).

T/F: Datura is no longer used in modern day.

False. Datura has been, and continues to be, used to fortify marijuana and opium preparations in the Far East and India. Cigarettes in these regions are made from leaves of Datura and Atropa which is smoked to produce an intoxicating effect which helped with asthma.

What happens when you ingest low doses of Datura?

It produces drowsiness and a dream like state with euphoria, a feeling or state of intense excitement and happiness. It also causes amnesia.

What happens when you overdoses on Datura?

It can produce more unpleasant hallucinations, delirium, and mental confusion.

How many seeds from Jimsonweed would cause an overdose?

10-20 produces a low-moderate dose. 50+ will cause an overdose that's fatal.

Why is Jimsonweed also known as the 'devil's trumpet'?

Because of the thorns covering the capsule/pod containing the seeds.

T/F: The 2013 OSDUHS reports that over the past year, Jimsonweed abuse was reported to be 10%.

False. The 2013 OSDUHS reports that over the past year, Jimsonweed abuse was reported to be 2%.

What are the effects of Henbane?

Effects are similar to other cholinergic antagonists.

What can be extracted from Henbane?

Scopolamine and hyoscyamine.

What does 'mandrake' mean?

It means 'potent male'.



What can be extracted from Mandragora Officinarum?

Atropine, scopolamine and hyoscyamine.



T/F: Mandragora Officinarum is a member of the potato/tomato family.

True.

What does medieval lore say about mandrake?

It is said that the plant grew wherever a hanged man's semen fell on the ground. Hence the term 'potent male'. The plant is named for the root because it looks like a person.

What is a common myth about the mandrake?

When the plant is uprooted, it shrieks and drives those that hear it mad (any HP fans?).

What were some common uses of the mandrake?

It was used in potions and as an aphrodisiac.



What are the effects of the Mandragora Officinarum at low doses?

It acts as a depressant and has been used as a sedative hypnotic type of drug.

What are the effects of the Mandragora Officinarum at high doses?

It produces hallucinations, delirium, and all the effects in cholinergic antagonists.

What are some plant substance examples for serotonergic or 5-HT like hallucinogens?

LSD, psilocybin mushrooms, DMT, lysergic acid amide, and bufotenine.

When and by whom was LSD first synthesized?

It was synthesized by Albert Hoffman in 1938 accidentally while studying derivatives of the ergot fungus for their vasoconstriction and uterus muscle toning abilities.

Why is it known as LSD-25?

Because the drug was synthesized on the 25th derivative of he ergot fungus.


What is the chemical name for 5-HT?

5-hydroxytryptamine

What does 'LSD' stand for?

Lysergic acid diethylamide

What is the minimal psychoactive dose of LSD-25?

About the size and weight of a grain of salt.



T/F: Hoffman coined the term 'psychedelic' with hallucinogens.

False. Dr. Humphrey Osmond, a British psychiatrist working in Canada, coined the term 'psychedelic' with these drugs.

What are some of the side effects of LSD-25?

Uncontrollable laughter, partial loss of memory of events while under influence of the drug, weightlessness that turns into "body is made out of lead" (no matter how hard you try, you cannot move), depersonalization, ego disintegration, synesthesia (seeing colors for sound), object trials (snapshots of a motion), time distortion (small periods last an eternity), form constants (close eyes= images of spirals, honeycombs, cobwebs, etc.), bad trips/panic attacks, and 'flashbacks',

What is 'ego disintegration'?

Difficulty distinguishing him/herself from the surroundings. This effect may be partially due to the analgesic effects of the drug. One user described the effects to as if their whole body had been injected with novocaine, and it was like touching your jaw at the dentist.

How often do you get flashbacks while under the influence of LSD?

You don't always get the flashbacks. Sometimes you get it weeks/months after consumption.

What is 'HPPD'?

HPPD is 'hallucinogen persisting perception disorder, a term used for more long lasting, distressing, recurring, and only slowly reversible psychedelic experiences occurring well after last drug use. prevalence is estimated to be about 4% of users.

T/F: LSD is a drug that has fatal effects.

False. LSD is fatal but not because of the effects. It is fatal because of what you do while under the influence.

T/F: Tolerance can occur to all of the hallucinogenic effects of LSD.

False. It can occur to most of the effects but not all.



T/F: Cross-tolerance is possible for LSD.

True.

T/F: There is evidence that Henry Beecher (the guy who discovered the placebo theory) contributes to the development of tolerance and physical dependence to LSD.

False. There is evidence that Pavlovian conditioning contributes to the development of tolerance to LSD. There is no evidence of physical dependence since there is no abstinence syndrome.

T/F: Subsequent research suggests there is no an LSD model of schizophrenia.

True. LSD is a visual drug and schizophrenia is auditory

T/F: In schizophrenia, a true hallucination is predominantly auditory and experienced with eyes opened.

True.

T/F: LSD produces true schizophrenic hallucinations.

False. LSD produces perceptual distortions that are largely visual (not auditory) which are experienced with eyes closed (as opposed to eyes open).

Compare suggestibility & communication with LSD users and schizophrenic patients

Individuals taking LSD = highly suggestible and communicative




Individuals with schizophrenia = resistant to suggestion and withdrawn

What does researchsuggests about LSD?

LSD suppresses firing of serotonin neurons in the raphe nuclei by acting as an agonist at presynaptic 5-HT1 receptors which serve as a negative feedback regulatory function on serotonergic activity.

What is the raphe nuclei?

The raphe nuclei is part of what is called the ascending reticular activating system (ARAS) which is involved in the filtering of sensory information.

What was the hypothesis from the research about LSD?

The hypothesis was that LSD interfered with this filtering leading to sensory distortions.

What is the consensus about the effects produced by LSD?

LSD produced it effects mainly via anagonistic action at post synaptic 5-HT2 receptors

Is there any research/evidence that counteracts the hypothesis about LSD?

Yes! Recent research suggests that the original mechanism of agonism at 5-HT1 suppressing rapheactivity is relevant.

T/F: LysergicAcid Amide (LSA) is a less potent, synthesized form of hallucinogenrelated to LSD.

False. LysergicAcid Amide is a less potent, but naturally occurring form of hallucinogenrelated to LSD.

From which plant(s) can LSA be found in?

LSA, aka ergine, can be found in ergot and sleepy grass

Identify this plant.

Identify this plant.

Sleepy Grass

Identify this plant.

Identify this plant.

Ergot (dark brown) on rye (golden).

What is the 'Holyfire' or 'St. Antony's Fire'?

This is a side effect of LSA that has been backed into bread made from infected grains. It is when there is a strong vasoconstriction which leads to a warm sensation, hence 'fire'. If the constriction lasts long enough, the affected limb will die and fall off.

What is ergotism?

It is a side effect of LSA; afflicted behaviour caused by ingestion of ergot.

T/F: Outbreaksof ergotism have occurred constantly in modern times.

False. Outbreaks occur occasionally.

What is the general name for 4-phosphoryl-dimethyltrypamine?

Psilocybin.

What is psilocybin?

It isa naturally occurring in a variety of mushrooms native to southern Mexico

What compound can be isolated from psilocybin and from which plant?

Tryptamine from many plants such as shrooms.

What does the body break psilocybin down to, if it metabolizes it at all?

Psilocin.

T/F: Psilocin is less lipid soluble than psilocybin, which means that it is more likely to pass the blood brain barrier.

False. Psilocin is more lipid soluble than psilocybin, which means that it is more likely to pass the blood brain barrier.

T/F: Psilocin is more lipid soluble than psilocybin, which means that it is more likely to pass the blood brain barrier.

True.

How many mushrooms will it take to have an LSA effect? How long will it take for the effects to begin? How long will the effects last?

Number of mushrooms to have an effect is 2-40, onset effects in about 30 mins,duration of 2-6 hours.

What is DMT and where can it be found/extracted from?

DMT is dimethyltryptamine and it can be found in Virola

Identify this plant.

Identify this plant.

Virola or Piptadenia Peregrina.

Where does virola grow?

Jungles of South and Central America where it is used by indigenous people.

What is the 'Business Man's Psychedelic'?

People took this drug during lunch hours, making it a drink that was ineffective because it was rapidly metabolized by monamine oxidase.

Describe the effects of DMT.

Rapid and short; onset is 10 sec post inhalation, peak effects in 10-15 minutes, and a duration of 60 minutes.

T/F: DMT sometimes contained harmaline alkaloids which blocked the action of monamine oxidase which allowed the effects to occur when taken orally.

True.

What is/are the most common way/ways form people to take DMT?

Inhalation and smoking, but can also be taken via injection.

What was the name of the drink that indigenous people made using DMT?

Ayahuasca.

What is 5-hydroxy-DMT and where can it be found?

Bufotenine which can be found in Piptadenia peregrina (a plant in Haiti and Venezuela), dream fish, and toads.

What is the unique side effect of bufotenine?

Cyanosis which is when the skinturns purplish blue.

What is this symptom called?

What is this symptom called?

Cyanosis.

T/F: There is a empirical evidence of seorotonergichallucinogens producing self-administration in either rodents or non-human primates.

False. There is little evidence proving that the serotonergichallucinogens produce self-administration in either rodents or non-humanprimates.

What are some plant substance examples for Methylated amphetamines (aka noradrenergic hallucinogens)?

Mescaline and MDMA

What is the name of this plant and are there any alternative names?

What is the name of this plant and are there any alternative names? What drug can be extracted from this plant? Describe the pH property of the drug.

Peyote Cactus, aka Lophophora williamsii. It is an active alkaloid that contains mescaline.

Which neurotransmitter do methylated amphetamines resemble?

Norepinephrine

Describe the effects of mescaline.

Effect duration is 10 hours and peaks within 60 minutes of administration. Intoxication is characterized by seeing 'vibrant colours'

T/F: Pastyear use around 20%. This represents a decline from 50% in the early 2000s.

False. Past year use around 3%. This represents a decline from 20% in the early 2000s

T/F: Thepropensity of mescaline to produce hallucinogenic properties is related tothe degree of agonist activity at 5-HT2 receptors.

True.

What does STP stand for?

Serenity, tranquillity, andpeace or 'Super Terrific Psychedelic'

Is DOM a naturally occurring drug or was it synthesized? Explain.

DOMwas synthesized by 'Dow Chemical' in 1964 as a potential appetite suppressor.

What is MDMA better known as?

Ecstasy

What does MDMA metabolize to? What is the street and chemical name for the metabolite?

MDA. The street name for this is EVE and the chemical name is 3-methoxy-4,5-methylenedioxyamphetamine.

What country first synthesized MDMA?

Germany

T/F: The root of sassafras tree formerly used in theproduction of root beer but now banned because of carcinogenic properties,contains a substance called safrole or shikimo, that can easily be converted toMDMA.


False. It can easily be converted to MDA.

What are some side effects of MDMA?

Tensionin the jaw, teeth grinding, high body temperatures (malignant hypothermia) anddehydration, a combination that has produced some deaths


Until what year was MDMA legal?

1986

T/F: MDMA is very effective in releasing dopamine and inhibiting serotonin.

False. MDMA causes the release of serotonin anddopamine, and is particularly effective in causing the release of serotonin.

Why is there a prolonged and intense period of serotonergic activation when taking MDMA and MDA?

They both block serotonin re-uptake which cause this prolonged effect, resulting in permanent neurotransmitter system damage.



T/F: MDMA and MDA has been shown to be a potent serotonergic neurotoxinin rats and non-human primates.

True.

T/F: Majorserotonin metabolite was lower in persons who had used MDMA between 30-50times vs non users

False. 80-100 times.

Which area(s) of the brain are a result of permanent lowering of serotenergic functioning?

Inbrain areas involving learning and memory damaged nerve endings do not regrowresulting in a permanent lowering of serotengergic functioning.


Which area(s) of the brain are a result of excess serotenergic release?

In brain areas involving sleep appetite there is excess regerneration resulting in excess serotonin release

Where can myristicin and elemicin be found?

Can be found in the fruit of the tree Myristica fragrans.

What can be derived from the seed/seed coats of this tree?

What can be derived from the seed/seed coats of this tree?

Nutmeg and mace.

Identify this plant.

Identify this plant.

Myristica fragrans.

T/F: It is difficult to establish self administration with phenethylamine hallucinogens.

True.

T/F: It is easy to establish self administration with phenethylamine hallucinogens.

False. It is difficult to do this.

T/F: Many methylated amphetamine type hallucinogens, like MDMA and MDA, are not self administered and don't produce conditioned place preference.

False. They do both of those things.

T/F: Many methylated amphetamine type hallucinogens, like MDMA and MDA, are self administered and produce conditioned place preference.

True.

What are some plant substance examples for other/miscellaneous drugs mentioned in the text notes?

Dissociative anaesthetics, like PCP and Ketamine, and salvinorin.

What does PCP stand for?

Phencyclidine.

What are some common street names for phencyclidine?

PCP, Angle Dust, and Horse Tranks (vets use this on hroses)

T/F: PCP can be taken orally in the form of a powder or liquid.

True.

What are some side effects of dissociative anaesthetics?

Euphoria, numbness, loss of motor control, catatonia (difficulty to move), initial nystagmus (difficulty moving eyes) which turns into a fixed stare (doll's eyes = look through/behind someone), distortion of body image with the perception that parts of the body are particularly large or small, paranoia, auditory hallucinations, extreme mood changes (no emotion to outburst), aggressive hostility, and stereotypies (repetitive body movement).

T/F: Tolerance can be developed in laboratory animals for dissociative anaesthetics.

True.

T/F: Physical cannot be developed in laboratory animals for dissociative anaesthetics.

False. It can be developed.

What are some withdrawal symptoms of dissociative anaesthetics?

tremors, oculomotor hyperactivity, fearfulness. diarrhea, and convulsions.

Can tolerance or physical dependence be developed in humans for dissociative anaesthetics?

Rarely because humans don't tend to use this drug.

What is the street name for ketamine?

Special K

What is the 'K-hole'?

A state that users describe which mimics the experiences of schizophrenia.

What does ketamine bind to?

Sigma Opiate Receptors

T/F: Ketamine is a bad model of psychosis.

False. It is a good model.

What does NMDA have to do with Ketamine?

It is thought that NMDA type glutamate receptors are also binding sites of ketamine.

What does the antagonims of the NMDA receptors produce?

It produces an increased dopaminergic activity in the brain's reward centres.

T/F: Only ketamine will be self administered by rats, monkeys, and dogs.

False. Both ketamine and PCP do this.

T/F: Only PCP will be self administered by rats, monkeys, and dogs.

False. Both ketamine and PCP do this.

T/F: Both ketamine and PCP will be self administered by rats, monkeys, and dogs.

True.



Does ketamine and PCP support conditioned place preference?

No

T/F: PCP and ketamine stimulate sigma opiate receptors and block NMDA receptors.

True.

T/F: PCP and ketamine stimulate NMDA receptors and block sigma opiate receptors.

False. PCP and ketamine stimulate sigma opiate receptors and block NMDA receptors.

T/F: PCP and ketamine stimulate sigma opiate receptors and NMDA receptors.

False. PCP and ketamine stimulate sigma opiate receptors and block NMDA receptors.

T/F: PCP and ketamine block sigma opiate receptors and NMDA receptors.

False.PCP and ketamine stimulate sigma opiate receptors and block NMDA receptors.

What is DM?

Dextromethorphan

What does DM do that is similar to both PCP and ketamine?

DM, PCP and ketamine stimulate sigma opiate receptors and block NMDA receptors.

What is the main ingredient of Robitussin?

DM

What is recreational use of DM referred to as?

Robo-coping. roboing, and robo-tripping

What are the following medicines for: guaifenesin, diphenydramine, and dimenhydrinate.

Cough medication, cold medication (benadyrl), and motion sickness (dramanine or gravol).

What are enthogens?

Naturally occurring plant substances that produce mystical or religious experiences.





Is salvia illegal?

Nope



What are the 3 most common administration methods of salvia divinorum?

Chewing a quid, smoking it in a cigarette, or making a tea.

What is another name for salvia divinorum?

Diviner's Sage

What is the active ingredient of salvia divinorum and which receptors does it effect?

Salvinorin A which exerts an agonistic action at kappa opioid receptors.


Identify this plant.

Identify this plant.

Salvia divinorum

What is the main ingredient of Absinthe?

Thujone which can be found in wormwood.



Identify this image.

Identify this image.

This is a bottle of Absinthe, aka the Green Fairy.

Identify this image.

Identify this image.

This is how you prepare a drink of Absinthe. Sugar cube on top, Absinthe poured over the cube, and the sugar falls inside.