Introduction
Background:
Atropine as an Alkaloid compound has been in use for ages since the times of the Roman Empire as it was used for local anesthesia. The compound was derived from common organic compounds like Tropane alkaloid that is synthesized by most solanacea family and also from berries of the plant Atropa belladonna. Comprehensive research on the compound Atropine was first carried out by German chemist Friedlueb Ferdinad Runge between 1795-1867, later German based pharmacist Heinrich F .G between the years 1799-1864 (Goodman & Ketchim, 2010). However, it was not until 1901 when German Chemist Richard Willstatter synthesized the crystalline form of the compound. Atropine is synthesized in the lab by the reaction of the chemical …show more content…
Research on screening the HO-1-u-1 for drug delivery by altering the internal factors of PH, osmolarity and permeation enhancers, the researchers (Yangfeng, Zhong, & Chow, 2008) show how the factors of PH, Osmolarity and permeability enhancers can affect the permeability if the lipophilic membrane and the ß-blockers are used. The identified factors are the important factors in drug design and formulation. The effect of the stated factors is also evaluated in the research by (Hanne & Rassing, 1999), so hey evaluate the response of TR 146 cell culture in terms of permeability in different PH ranges, osmolarity values and bile salts. The study concludes by stating that the study of TR 146 cell culture properties is important in vitro studies model for studied on enhancers and research on buccal drug delivery. For instance, they are particularly important in determining the physiological osmolarity of the cell membranes and the permeability of the sublingual mucosa to drugs hence, they are relevant in the modeling of the best in vitro mechanisms for sublingual drug delivery that is important in designing atropine sulphate sublingual
Background:
Atropine as an Alkaloid compound has been in use for ages since the times of the Roman Empire as it was used for local anesthesia. The compound was derived from common organic compounds like Tropane alkaloid that is synthesized by most solanacea family and also from berries of the plant Atropa belladonna. Comprehensive research on the compound Atropine was first carried out by German chemist Friedlueb Ferdinad Runge between 1795-1867, later German based pharmacist Heinrich F .G between the years 1799-1864 (Goodman & Ketchim, 2010). However, it was not until 1901 when German Chemist Richard Willstatter synthesized the crystalline form of the compound. Atropine is synthesized in the lab by the reaction of the chemical …show more content…
Research on screening the HO-1-u-1 for drug delivery by altering the internal factors of PH, osmolarity and permeation enhancers, the researchers (Yangfeng, Zhong, & Chow, 2008) show how the factors of PH, Osmolarity and permeability enhancers can affect the permeability if the lipophilic membrane and the ß-blockers are used. The identified factors are the important factors in drug design and formulation. The effect of the stated factors is also evaluated in the research by (Hanne & Rassing, 1999), so hey evaluate the response of TR 146 cell culture in terms of permeability in different PH ranges, osmolarity values and bile salts. The study concludes by stating that the study of TR 146 cell culture properties is important in vitro studies model for studied on enhancers and research on buccal drug delivery. For instance, they are particularly important in determining the physiological osmolarity of the cell membranes and the permeability of the sublingual mucosa to drugs hence, they are relevant in the modeling of the best in vitro mechanisms for sublingual drug delivery that is important in designing atropine sulphate sublingual