Chemo

Front 1

Alkylating agents

Back 1

Act directly on DNA to prevent the cell from dividing; cell cycle phase nonspecific; generally of greatest value in treating slow- growing cancers (not as effective on rapidly growing cells)

Hint 1

Mustard gas derives: Cytoxan, Ifosfamide

Metal salts: Carboplatin, Cisplatin, Oxaliplatin

Front 2

Antimetabolites

Back 2

Replace natural substances as building blocks in DNA molecules, thereby altering the fxn of enzymes required for cell metabolism & protein synthesis; cell cyle specific - primarily act upon cells undergoing synthesis of new DNA for formation of new cells

Hint 2

Folic acid antagonist: MTX

Pyrimidine antagonist: 5FU, cytarabine, capecitabine, gemcitabine

Front 3

Plant alkaloids

Back 3

Act specifically by blocking the ability of a cancer cell to divide & become 2 cells; cell cycle specific (S- & M- phases)

Hint 3

Vinca alkaloids: Vincristine, Vinblastine, Vinorelbine

Taxanes: Paclitaxel, Docetaxel

Camptothecan analogs: Irinotecan, Topotecan

Podophyllotoxind: Etoposide

Front 4

Antitumor antibiotic

Back 4

Act by binding w/ DNA and preventing RNA synthesis, a key step in the creation of proteins, which are necessary for cell survival --> cause DNA to uncoil to prevent the cell from reproducing; cell cycle nonspecific?

Hint 4

Anthracyclines: Doxorubicin, daunorubicin, epirubicin, mitoxantrone, idarubicin

Chromomycins: dactinomycin

Miscellaneous: mitoxantrone, bleomycin

Front 5

Topoisimerase inhibitors

Back 5

Topoisomerase enzymes control the manipulation of the structure of DNA necessary for replication

Hint 5

I inhibitors: Irinotecan, Topotecan

II inhibitors: Etoposide

Front 6

Topoisimerase inhibitors

Back 6

Topoisomerase enzymes control the manipulation of the structure of DNA necessary for replication

Hint 6

I inhibitors: Irinotecan, Topotecan

II inhibitors: Etoposide