Cell Organelles

Front 1

Nuclear Envelope (membraneous or not?)

Back 1

Membraneous

Front 2

Mitochondria (membraneous or not?)

Back 2

Membraneous

Front 3

Golgi Apparatus (membraneous or not?)

Back 3

Membraneous

Front 4

ER (membraneous or not?)

Back 4

Membraneous

Front 5

Lysosome (membraneous or not?)

Back 5

Membraneous

Front 6

Peroxisome (membraneous or not?)

Back 6

Membraneous

Front 7

Nucleolus (membraneous or not?)

Back 7

Non

Front 8

Free ribosome

Back 8

Non

Front 9

Microtubules

Back 9

Non

Back 10

Non

Front 11

Microfilaments

Back 11

Non

Front 12

Intermediate filaments

Back 12

Non

Front 13

Euchrmoatin in nucleus stains ____ and are/are not clumped

Back 13

Light

Front 14

Heterchromatin in nucleus stains ____ and are/are not clumped

Back 14

Dark

Front 15

Smooth ER are/are not studded with ribosomes

Back 15

Are not

Front 16

Three functions of smooth ER

Back 16

Membrane synthesis, lipid synthesis, drug detioxification

Front 17

Location of smooth ER in body

Back 17

Abudant in liver, adrenal cortex

Front 18

Rough ER are/are not studded with ribosomes

Back 18

Are

Front 19

Function of Rough ER

Back 19

Protein synthesis for export

Front 20

Location of rough ER

Back 20

Abudant in plasma cell

Front 21

What are polyribosomes?

Back 21

Groups of ribosomes bound by mRNA

Front 22

What is the function of polyribosomes?

Back 22

Used for protein synthesis for internal utilization in cells

Front 23

What has many polyribosomes?

Back 23

Basophilic errythroblasts dedicated to synthesis of hemoglobin

Front 24

Two functions of Golgi bodies

Back 24

Contains many enzymes to finish protein synthesis begun in RER destined for secretion

Front 25

Appearance/Faces of Golgi Bodies

Back 25

Cis Convex Golgi Network (CGN), Trans concave Golgi Network (TGN)

Front 26

Define lysosome

Back 26

Membrane bound space

Front 27

Lysosomes are produced in the

Back 27

Golgi apparatus

Front 28

Function of lysosomes

Back 28

Degrade foreign antigens, cell debris, turnover of ECM

Front 29

Define lysosomal storage disease

Back 29

Defects in some lysosomal enzymes

Front 30

Examples of lysosomal storage disease

Back 30

Hurler and Hunter syndrome

Front 31

How many membranes does a mitochondria have?

Back 31

2 (inner and outer)

Front 32

Where are mitochondria found?

Back 32

Where ATP is consumed

Front 33

What does a mitochondria do?

Back 33

Produces ATP and ADP and energy derived from oxidation and food substances

Front 34

Define: Leigh Disease

Back 34

Progressive, severe childhood neurodegenrative disease (necrotizing encepolopathy)

Front 35

Cause of Leigh disease

Back 35

Autosomal recessive mutation in mitochondria enzyme pathway converting pyruvate to ATP

Front 36

Characteristics of Leigh's Disease

Back 36

Lactic acidemia, development delays, muscle weakness, seizures

Front 37

Components of cytoskeleton

Back 37

Microtubules, actin filamernts, intermediate filaments

Front 38

Microtubules are composed of _____

Back 38

Alpha and beta tubulin dimers arranged head to tail with microtubule organizing center

Front 39

Five functions of microtubules

Back 39

Maintain shape of cell-axons, organize into mitotic spindles; organize into centrioles, cilia and flagella, intracelluar transport, dynamic assembly and disassmbly

Front 40

Actin filaments are composed of

Back 40

G actin subunits polymerized into F-actin-ADP and Pi

Front 41

In microvilli, filaments are bundled and stabilized by ____

Back 41

Fascin and fibrin

Front 42

____dissolves actin gels at high Ca

Back 42

Gelsolin

Front 43

In muscle actin filaments arrange in a _________________.

Back 43

Paracrystaline network

Front 44

Actin filaments in muscle are associated with ___

Back 44

Troponin and tropomyosin

Front 45

Description of intermediate filaments

Back 45

Rope like aggregates of monomers

Front 46

Function of intermediate filaments

Back 46

Provide general support for the cell

Front 47

Examples of intermediate filaments

Back 47

Keratin (form support for desmosomes),

Front 48

Examples of intermediate filaments

Back 48

Vimentin family - vimentin (connective tissue), desmin (muscle), GFAP (glia); neurofilaments, laminins

Front 49

Two more examples of intermediate filaments

Back 49

Neurofilaments (neurons), lamins (nuclear envelope)

Front 50

Gout Definition

Back 50

Accumulation of uric acid crystals in diarthroidal joints

Front 51

Gout symtoms

Back 51

inflammation and painful swelling

Front 52

Gout treatment

Back 52

Colchichine

Front 53

Mechanism of colchichine

Back 53

Blocks instability of microtubules and prevents immigration of inflammatory cells

Front 54

Name of anti-cancer drugs

Back 54

Vinablastine, taxol, etoposide

Front 55

Mechanism of chemo

Back 55

GI distress, hair loss, susecptibility to infections resulting from blocking normally dividing cells

Front 56

Genus of poiseonous mushroom

Back 56

Amanita

Front 57

Name of peptide in mushrooms

Back 57

Phalloidin

Front 58

Mechanism of phalloidin

Back 58

Binds to and inacvtivates microfilaments

Front 59

Effects of phalloidin

Back 59

Severe liver damage

Front 60

Description of Alzheimer's

Back 60

Neurofibrillary tangles, dsposits around blood vessels and plaque formation

Front 61

Causes of symptoms of Alzheimer's

Back 61

Accumulation of tubulin in NFTs

Front 62

This protein alters the dynamic instability of tubulin and results in accumulation of NFTs

Back 62

Tau protein

Front 63

Define: Mallory bodies

Back 63

Abnormal accumulation of intermediate filament keratin in hepatocytes from excess alcohol consumption (kill liver cells)