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17 Cards in this Set

  • Front
  • Back
TCA cycle overview
Acetyl group of acetyl CoA completely oxidized to Co2
Electrons removed from acetyll transferred to NAD+ and FAD
! GTP formed substrate level phosphorylation.
The link thiol ester bond in acetyl CoA
is high in energy
NADH and FADH2 formed during cycle deoxidized to NAD+ and FAD through action of respiratory or electron transport chain
Oxygen got reduced to water, creat a proton gradient with couple to the surfaces of ADP to make ATP.
One phosphorylation in the citric cycle and many more
delightfully not difficult reactions.
Pyruvate + CoA + NaD+ -> acetyl CoA + CO2 + NADH
oxidation of pyruvate that releases CO2. The first decarboxylation and couple it the CoA.
This process is irreversible, catalyzed
The pyruvate dehydrogenase complex
Locate in mitochondria
3 distinct enzymes associated in a huge protein/coenzyme complex (60 ppolypeptide chains)
E1 ( Thiamine pyrophosphate) E2 (lipoic acid ), E3 (FAD)
The reaction is irreversible ( both decarbonxylation and oxidation )
The pyruvate dehydrogenase reaction is irreversible and highly regulated
The pyruvate dehydrogenase reaction is irreversible and highly regulated.
Not possible to synthesize carb's from acetyl CoA
Inhibited by end products NADH and acetyl CoA
Switched off by phosphorylation
Increase NADH/NAD+, acetyl CoA/ CoA or ATP/ADP promotes phosphorylation.
Pyruvate, ADP inhibit phosphorylation.
Reactions of the TAC cycle
enter the citric cycle as a 2 carbon unit and reacts with a 4 carbon compound to form 6 carbon compound and lead to 5 carbon compound , oxiadated decarboxylation form NADH and FADH2
next step is phosphorylation.
Acetyl group of acetyl CoA completely oxidized to Co2
Citrate synthase
oxaloacetate got converted to citrate via the addition of actetyl coenzyme A ( a symetric molecule)
The citrate group isomerized into isocitrate with
Isocitatrate dehydrogenase
Decarboxylate the isocitrate and transfer proton to NAD+ to form NADH , thus generate alpha-ketoglutarato
alpha-ketoglutarato dehydrogenase complex
this got converted into succinyl CoA
Succinyl CoA Synthase
phosphorylate GDP to GTP and from succinase
Succinate dehydrogenase (not in mitochondria but in the membran-bound iron sulfur protein )
form Fumarte and gives a H to FADH2
Well , convert fumerase into malate ( malic acid)
malase dehydrogenase
Convert malate into oxoacetate and generate NADH fro NAD+