Biochemistry Ch. 17

Front 1

During the Citric Acid Cycle one acetate enters the cycle and eventually is able to produce:

Back 1

Two CO2 molecules, 8 high energy electrons, and GTP

Front 2

When fumarate is converted to malate in the Citric Acid Cycle:

Back 2

One water is used only

Front 3

The first CO2 released during from citrate comes from:

Back 3

The carboxylate carbon atom located nearest the ketone group of oxaloacetate

Front 4

Pyruvate dehydrogenase

Back 4

All of the above

Front 5

The dehydration of malate

Back 5

Produces oxaloacetate

Front 6

During the complete cycle of pyruvate dehydrogenase activity:

Back 6

All of the above

Front 7

Regulation of the citric acid cycle primarily takes place at steps that:

Back 7

Steps that produce new products that can be used by the cell

Front 8

It is not possible in a complex pathway like the citric acid cycle to contain a step that requires large amounts of energy.

Back 8

False

Front 9

CoA is utilized during the citric acid cycle only during the formation of Acetyl CoA, which is eventually metabolized by the cycle.

Back 9

False

Front 10

Puruvate dehydrogenase

Back 10

All of the above

Front 11

In pyruvate dehydrogenase the acetate is transferred from one member of the enzyme complex to another. What coenzyme is responsible for this transfer?

Back 11

Lipoic Acid

Front 12

The energy to drive citrate formation from acetyl CoA and oxaloacetate comes from

Back 12

All of the above

Front 13

From what molecule is the energy derived to form the CoA linkage in pyruvate dehydrogenase; i.e., which does CoA displace?

Back 13

Lipoic Acid

Front 14

Which of the following enzymes of the Citric Acid Cycle are highly regulated according to our discussions in class?

Back 14

None of the above.

Front 15

Draw the structure of the molecule formed in the citric acid cycle by condensation of acetyl-CoA and oxaloacetate and indicate which carbons would have been derived from acetyl CoA.

Back 15

The top two carbons (or equivalently the bottom two carbons) are from Acetyl CoA

Front 16

From succinate to oxaloacetate two high-energy molecules are formed. What can be said about this reaction?

Back 16

A FADH2 is formed upon the conversion of a C-C bond to a C=C.

Front 17

Which step in the citric acid cycle involves attachment of CoA?

Back 17

Dehydration of alpha-ketoglutarate

Front 18

Describe the carbon released as CO2 upon dehydration of isocitrate.

Back 18

does not come from pyruvate

Front 19

Draw the structure of the member of the citric acid cycle containing CoA. (This is not related to Acetyl CoA.)

Back 19

Front 20

How many high-energy electron-containing molecules are generated by the citric acid cycle? Name them

Back 20

3 NADH and 1 FADH

Front 21

How is oxaloacetate regenerated in the citric acid cycle?

Back 21

By dehydration of malate

Front 22

Cytochrome C is:

Back 22

freely soluble in the inter-membrane space

Front 23

From succinate to oxaloacetate two high-energy molecules are formed. What can be said about this reaction?

Back 23

A FADH2 is formed upon the conversion of a C-C bond to a C=C.

Front 24

The first CO2 released during from citrate comes from:

Back 24

The carboxylate carbon atom located nearest the ketone group of oxaloacetate

Front 25

The dehydration of malate

Back 25

Produces considerable energy