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34 Cards in this Set
- Front
- Back
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Epitope |
Determinants of antigenicity |
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Antigenic |
Term: recognized as foreign by host prrs and antibodies |
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Antigen |
Any substance that can bind to an antibody or TCR |
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Immunogen |
Substance that elicits an immune response |
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T |
[T/F]: All immunogens are antigen, not all antigen are immunogen |
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Size, complexity, form |
Intrinsic properties of immunogen |
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Dose, route, foreigness |
Extrinsic property of immunogen |
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> 10 000 mW |
Immunogen size |
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Polymer (>monomer), aggregated (>soluble) |
Complexity and form of immunogen |
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10 microgram to 1g, parenteral |
Immunogenic in terms of dose and route |
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Hapten |
Low mW molecules that can only bind to antibodies but not induce immune response |
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F |
[T/F]: Nucleic acids, simple polysaccharides with repeating subunits and lipids are good immunogens |
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Soluble molecule is not easily phagocytosed |
Why is soluble form not a good immunogen |
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T |
[T/F]: extremely high/low doses may suppress an immune response by stimulating tolerance |
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Molecules is degraded before introduction to phagocyte |
Cons for introducing immunogen via oral route |
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OPV (polio) , rotavirus |
Oral vaccines |
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Diptheria-tetus-pertussis, hepa B, IPV, Hib, PCV-7 |
Intramuscular vaccine (5) |
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Measles, yellow fever |
Subcutanous vaccine |
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BCG (tuberculosis) |
Intradermal vaccine |
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Binary complex Ag-Ig, ternary complex TCR-Ag-MHC |
B cell vs T cell: Interaction with antigen |
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Yes, No |
B cell vs T cell: Binding of soluble antigen |
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None, required |
B cell vs T cell: Involvement of MHC |
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Protein, ploysaccharide, lipid; protein or lipid/glycolipid presented on MHC |
B cell vs T cell: Chemical nature of antigens |
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Accessible, hydrophilic, mobile |
Epitope properties of those recognized by B cell |
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Internal linear peptided |
Epitope properties of those recognized by TCR |
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T cell surface glycoprotein |
T cell part: Recognizes MHC |
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Homologous |
Antigen that induces antibody or TCR |
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Heterologous |
Non-inducing antigens that react with antibody |
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Cross reaction |
Interaction between antibody/TCR + heterologous antigen |
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Alpha, beta chains; disulfide bond |
Chain of tcr, bond between them |
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Variable domains of alpha and beta chains |
Interact to make binding site in TCR |
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On surface of nucleated cells |
Whete mhc i are found |
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Surface of APCs: B cells, macrophages, DCs |
Where mhc ii are found |
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Cd8+, cd4+ |
Class1/2: recognition |
