Medical Immunology Dickinson Lecture 10 Antigen Presentation And Lymphocyte Activation

Front 1

As dedritic cells mature, they express more ________ on their surface

Back 1

MHC

Front 2

What are the two types of dendritic cells in the skin?

Back 2

epidermal (langerhahn's) cells, dermal (interstitial) cells

Front 3

Blood DC's are predominantly ____________ DC's and produce type __ interferons

Back 3

plasmacytoid; I

Front 4

DC's in the intestine are ________ DC's

Back 4

myeloid

Front 5

__________ DC's are the population that are permanent residents of the secondary lymphoid tissue

Back 5

follicular

Front 6

DC's generally present viruses on MHC Class ____ molecules and bacteria on Class ___ molecules

Back 6

I: II

Front 7

what are the three types of antigen presenting cells?

Back 7

macrophages, dendritic cells, b cells

Front 8

How do naive T cells enter lymph nodes?

Back 8

through blood or lymph

Front 9

B7 molecules on APC's are _________ molecules that bind to ________ on the T cell

Back 9

co-stimulatory; CD28

Front 10

Activated T cells secrete and respond to IL-____ which is required for T cell proliferation

Back 10

2

Front 11

What do superantigens do?

Back 11

bridge TCR and MHC in the absence of a specific peptide (toxic shock, food poisoning)

Front 12

Binding of B7 to CTLA-4 induces _________

Back 12

tolerance

Front 13

what happens when an APC binds to a naive T-cell with a specific signal but no B7?

Back 13

T-cell becomes anergic

Front 14

What happens when an APC binds the co-stimulatory signal (B7) but no specific antigen signal to a naive T-cell?

Back 14

no effect on the T cell

Front 15

TGF-beta from APC's drives naive CD4 T-cell differentiation into what subset?

Back 15

Treg cell or Th17

Front 16

IL-6 drives a naive CD4 T-cell towards what subset?

Back 16

Th17

Front 17

IL-12 drives a naive CD4 T-cell toward what subset?

Back 17

Th1

Front 18

IL-10 drives a naive CD4 T-cell toward what subset?

Back 18

Th2

Front 19

Th1 cells seek out and activate __________

Back 19

macrophages

Front 20

Th2 cells seek out and activate _____________

Back 20

B-cells

Front 21

Activated T-cells require a co-stimulatory signal and specific antigen signal to perform their effector function (true/false)

Back 21

false (only naive T cells require both to become active)

Front 22

antigen binding to b-cell receptor provides the first activation signal. what provides the second?

Back 22

T-helper cell delivers second signal via CD40 ligand and cytokines

Front 23

what are the two forms of T-independent antigens?

Back 23

TI-1 and TI-2

Front 24

What are the consequences of b cell activation in the absence of T cell help?

Back 24

no T helper cytokines -> no isotype switching (IgM antibodies only); no affinity maturation (low affinity antibodies); no memory response