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20 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
Three initial responses to vascular injury
Vasoconstriction, platelet adhesion, thrombin generation
Intrinsic pathway = __ + __ + __ + __
exposed collagen, prekallikrein, HMW kininogen, factor XII
Intrinsic pathway cascade
XII --> XI --> IX + VIII --> X + V ---> convert prothrombin (factor II) to thrombin --> thrombin converts fibrinogen to fibrin
Extrinsic pathway sequence
TF (injured cells) + factor VII --> activate X, then add V --> convert prothrombin to thrombin --> thrombin converts fibrinogen to fibrin
Prothrombin complex consists of __
X, V, Ca, platelet factor 3, and prothrombin. Where does it form? What does it catalyze?
On platelets. Formation of thrombin.
What is the convergence point for both intrinsic and extrinsic pathways?
Factor X
___ combines with platelets to form ____, leading to ___
Fibrin, platelet plug, hemostasis
Which factor helps crosslink fibrin?
What are thrombin's roles?
Key to coagulation, converts fibrinogen to fibrin and fibrin split products, activates factors V and VIII, activates platelets
How does antithrombin III work?
Binds and inhibits thrombin, inhibits factors IX, X, XI
Protein C MOA
degrades fibrinogen
Protein S MOA
Protein C cofactor
tPA is released from ___ and works by ___
endothelium, converts plasminogen to plasmin
Plasmin functions by ___
degrading factors V and VIII, fibrinogen and fibrin
Factor with shortest half life
Factor VII
Labile factors. Activity lost in stored blood.
Factors V and VIII. Activity isn't lost in ___.
Only factor not synthesized in liver. Synthesized in ___.
VIII, endothelium
Vitamin K takes ___ hours to take effect
FFP's effect lasts __ hours
Normal half life of RBCs, platelets, PMNs:
120 days, 7 days, 1-2 days