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17 Cards in this Set
- Front
- Back
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Hepatitis 🦠: naked, ssRNA, +ve sense |
A + E |
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Hepatitis 🦠: Enveloped, ssRNA, +ve sense |
C + G |
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Hepatitis 🦠: Enveloped, circular, dsDNA |
B |
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Hepatitis 🦠: Defective, circular ssRNA |
D |
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Clinical Presentation of Hepatitis |
Asymptomatic Jaundice (late) Anorexia 🤢🤮 RUQ pain Increased AST + ALT |
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Replication process of Hepatitis A |
Receptor binding RNA uncoating Translation + proteolytic processing RNA replication Virions assembly Maturation + release |
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Hepatitis A: Transmission |
Fecal-oral - contaminated 💧 + food (esp 🦀) Person to person Food borne Water borne Vertical Blood borne (rare) |
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Hepatitis A: Epidemiology + Risk Factors |
Epi: developing countries + rural areas Risk factors: kids in daycare, military |
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Hepatitis A: patho |
Virus enters via gut -> replicates in liver cells -> passes thru bike duct -> shed in stool Necrosis of liver (peri portal areas) + Proliferation of Kuppfer + endothelial cells Transient viremia No carrier state no chronic state |
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Hepatitis A: Diff dx |
Hep E, B, C, D Alcoholic hepatitis Autoimmune hepatitis Viral hepatitis |
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Hepatitis A: Diagnosis |
ELISA - detects HAV specific IgM RIA + EIA - Anti HAV IgM + G in saliva + urine IF - Anti HAV IgM + G in stool |
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Hepatitis A: rx |
Supportive bc no antiviral rx available |
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Hepatitis A: prevention |
Active immunization - inactivated HAV vax (Havrix + Vaqta) Passive - post exposure -> HAV immunoglobulin |
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Hepatitis A: complications |
Prolonged cholestasis - pruritus, 🤒 💩 weight loss + bilirubin > 10 |
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Hepatitis E: diagnosis |
EM - Calcivirus-like particles in stool ELISA - specific IgM + G RT-PCR - HEV RNA in stool + serum |
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Hepatitis E: rx |
Supportive |
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Hepatitis E: prevention |
No vaccines Only proper sanitary measures! |
