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56 Cards in this Set
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1. A transdermal fentanyl patch is often used for management of cancer pain. After application, the time to reach peak plasma levels is: * A. 1hr |
E. 24 hrs
ANZCA pain book 6.5.1 "The time to peak blood concentration is generally between 24 and 72 hours after initial patch application and after the patch is removed, serum fentanyl concentrations decline gradually, with a mean terminal half‐life ranging from 22 to 25 hours" (MIMS, 2008) |
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2. Pharmacological studies are undertaken in several phases. A phase 3 study involves: * A Animal studies |
E. RCT in target population ("full scale evaluation")
Myles textbook p.137 Phase I: first administration in humans (usually healthy volunteers). Confirm/establish basic PK and toxicology data. (n=20-100)
Phase II: selected clinical investigations in target population, aimed at establishing dose-response ('dose finding') relationship, plus some evidence of efficacy and safety
Phase III: full scale clinical evaluation of benefits, potential risks and cost analyses
Phase IV: post marketing surveillance (thousands of patients) |
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3. A pregnant patient 28/40 gestation is involved in a high-speed MVA. On admission to the DEM she complains of sudden onset severe chest pain. Her vital signs show HR 120, BP 160/100, SpO2 95% RA and her ECG shows ST depression. Most likely diagnosis is: * A. Cardiac contusion |
C. Aortic dissection (blunt chest trauma + pregnancy both risk factors)
http://www.nlm.nih.gov/medlineplus/ency/article/000181.htm |
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4. A 5 year-old child with recently diagnosed Duchenne muscular dystrophy has an inhalation induction with sevoflurane for closed reduction of a distal forearm fracture. No other drugs have been given. 10 minutes later the child suffers a cardiac arrest. After a further 5 minutes a venous blood sample shows a potassium level of 8.5mmol/L. The most likely mechanism for the hyperkalaemia is: * A MH |
D. Rhabdo
CEACCP. NM disorders and anaesthesia. http://ceaccp.oxfordjournals.org/content/early/2011/06/10/bjaceaccp.mkr019.full.pdf
"Inhalation anaesthetics have been implicated in the rhabdomyolysis seen in Duchenne muscular dystrophy patients secondary to their effects of further increasing mycoplasmic calcium. It has been difficult to elucidate whether the metabolic reaction seen is related to an anaesthesia-related rhabdomyolysis or a true malignant hyperthermia."
Ped Anaesth study http://anes-som.ucsd.edu/Intranet/Peds_Resources/MH/Malignant%20hyperthermia%20and%20MD.pdf
We did not find an increased risk of malignant hyperthermia susceptibility in patients with DMD or BD compared with the general population. However, dystrophic patients who are exposed to inhaled anesthetics may develop disease-related cardiac complications, or rarely, a malignant hyperthermia-like syndrome characterized by rhabdomyolysis |
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52. A 30yr old pregnant patient develops contractions at 30/40 gestation. Which of the following can not be used for tocolysis? A. Clonidine B. Indomethacin C: Magnesium D. Salbutamol E. Nifedipine |
A - clonidine has no tocolytic effect |
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53. In a patient with intraorbital haemorrhage, following local anaesthetic injection, the adequacy of occular perfusion is best assessed by: * A. Angiography |
B
Royal college of anaesthetists and opthalmologists consensus document http://www.rcoa.ac.uk/system/files/LA-Ophthalmic-surgery-2012.pdf Document page 26
"Indirect ophthalmoscopy should be performed to look for evidence of central retinal artery perfusion compromise" |
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54. What is the appropriate post-operative ibuprofen dosage for a one year old child tds? * A. 5mg/kg |
C. 10 mg/kg
Frank Sham drug doses |
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55. You are inducing a 4yr old child with Arthrogrophysis multiplex congenita. After you administer the induction agents, you find it difficult to place the laryngoscope. What is the likely complication? * A. Malignant hyperthermia |
C |
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56. What is the best measure of the anticoagulant effect of Dabigatran? * A. APTT |
B. Dilute thrombin time
Horlocker article.
http://www.chumontgodinne.be/files/PradaxaPracticalquestionsFinalSept2011.pdf
In situations where an assessment of the anticoagulant activity of dabigatran is required, the activated partial thromboplastin time (aPTT) test, which is widely available, provides an approximate indication of the anticoagulation intensity achieved with dabigatran.
If required, a more sensitive quantitative test with the diluted Thrombin Time (Hemoclot®) can be performed.
The INR is less affected by dabigatran and should therefore not be used. |
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57. What is the ratio of compression to breaths for neonatal resuscitation? * A. 3:1 |
A. 3:1 (ARC neonatal resus guidelines) |
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60. In patients with refractory elevated ICP, bilateral decompressive craniectomy is associated with reduction in ICP and also results in: * A. Reduced duration of ventilation
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E. No change long-term outcome
Cochrane review: http://www.ncbi.nlm.nih.gov/pubmed/16437469 "There is no evidence to support the routine use of secondary DC to reduce unfavourable outcome in adults with severe TBI and refractory high ICP. In the pediatric population DC reduces the risk of death and unfavourable outcome."
2014 article: http://www.ncbi.nlm.nih.gov/pubmed/24662856 |
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61.Tumour lysis syndrome causes all of the following biochemical abnormalities EXCEPT: * A. Hyperkalaemia |
B. Hypernatraemia (all other changes occur)
Medscape: http://emedicine.medscape.com/article/282171-overview#showall Clinically, the syndrome is characterized by rapid development of hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and acute renal failure.
CEACCP. Intensive care management of patients with haematological malignancy. http://ceaccp.oxfordjournals.org/content/10/6/167.full
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76. A patient has suffered flash burns to half of the left upper limb, all of the left lower limb and the anterior surface of the abdomen. The approximate percentage of the body surface which has been burnt is: * A. 18%* B. 23% * C. 32% * D. 41% * E. 48% |
C. 32%
Rule of 9's: Half of upper limb: 4.5 All of lower limb: 18 Anterior surface abdomen: 9 |
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77. You are anaesthetising an ASA 1 woman for a laparoscopic gynaecological procedure. How long does it take for the PaCO2 to peak? * A. <15min* B. 15-30min * C. 30-60min * D. 60-90min * E. >90min |
B. 15-30 min
See: http://web.squ.edu.om/med-Lib/MED_CD/E_CDs/anesthesia/site/content/v04/040260r00.HTM
During uneventful CO2 -pneumoperitoneum, PaCO2 progressively increases to reach a plateau 15 to 30 minutes after the beginning of CO2 insufflation in patients under controlled mechanical ventilation during gynecologic laparoscopy in the Trendelenburg position |
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82. Anaemia post partial gastrectomy is most likely due to: * A folate deficiency secondary to steatorrhea* B ongoing haemorrhage from stomal ulcer '(yes Stomal not stomach)' * C malabsorption of iron * D Vit B deficiency due to loss of intrinsic factor * E folate deficiency due to lack of appetite |
C. Iron |
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83.: 65year old for video assisted thoracoscopic lower lobe wedge resection. Surgeon requests lung isolation and one lung ventilation. Predictors of intraoperative hypoxia are: * A central rather than peripheral lesion* B left sided lesion * C low Aa Oxygen gradient when ventilating both lungs * D right sided lesion * E supine rather than lateral position |
A,D and E all predictors of intraop hypoxia. ?Poor recall (possibly all except..)
CEACCP. Hypoxaemia during one-lung anaesthesia http://ceaccp.oxfordjournals.org/content/10/4/117.full
Factors predictive of hypoxaemia during OLV include: ventilation of the left rather than the right lung, low oxygen partial pressure on two lungs, absence of reduction of perfusion to areas of lung pathology, and supine position rather than the lateral decubitus position |
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94. Small air bubbles in the arterial line system will reduce: * A. Dampening coefficient* B. ?Extrinsic Coefficient * C. Measured systolic pressure * D. Measured MAP * E. Resonant frequency |
C. air bubbles -> overdamped system -> reduce measured SBP (MAP stays the same)
?If resonant frequecy will reduce in this setting too
CEACCP. Blood pressure measurement http://ceaccp.oxfordjournals.org/content/7/4/122.full |
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Q95: RPT. Capnograph trace form a patient that is intubated and ventilated. What does it indicate See previous paper for a picture, it was the same * A. Endotracheal intubation |
B. Gas sample line leak |
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Photograph and Ultrasound picture of regional block. probe held transverse against posterolateral aspect of distal humerus over triceps. shows triangular nerve in close proximity to humerus. After infiltration of 5mls of 0.75% ropivacine Numbess in: * A lateral aspect of forearm |
Sounds like image of radial nerve.. None of answers correspond with radial nerve sensory distribution
Options: A. musculocutaneous nerve B. ulnar nerve (dorsal ring finger) C. D. ulnar nerve E. median nerve |
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Lateral CXR given. Can see lower half of thorax and vertebrae but upper half is all black with clear demarcation * A ? |
Something either side of horizontal fissure. |
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12 year-old with idiopathic scoliosis, most likely have associated * A Phaemochromocytoma
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C. Mitral valve prolapse
Approximately 25% patients with idiopathic scoliosis have mitral valve prolapse, but this is rarely of clinical significance and antibiotic cover is given
CEACCP. Scoliosis surgery http://ceaccp.oxfordjournals.org/content/6/1/13.full |
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Term neonate, noted to have intermittent stridor few days after birth, then parents also notice stridor during feeding and sleep. Otherwise normal and healthy. Most likely condition is * A Cri-du-chat syndrome |
B. Laryngomalacia
Laryngomalacia - most common cause of chronic pediatric stridor causing approximately 60% of stridor seen in newborns.
http://www2.utmb.edu/otoref/Grnds/Stridor-infants-980415/Stridor-infants-980415.html |
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A picture of an echo 4 chambers view * A Anterior mitral valve leaflet |
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Cryoprecipate, once thawed must use within * A 30 minutes |
D. 6 hours
http://lifeinthefastlane.com/ccc/cryoprecipitate/
http://www.childrensmn.org/manuals/lab/transfusionsvc/018717.pdf |
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Glycine 1.5% used for TURP, osmolality is * A 200
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A. 200
CEACCP. Anaesthesia for transurethral resection of the prostate
http://ceaccp.oxfordjournals.org/content/9/3/92.full
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Sick ICU patients seem to have moderate - severe ARDS PaO2/FIO2 ratio of 200, C.I. 1.7 (cardiac function seems okay). Decided to have ECMO, best mode is A AV B VA C VV D. ? |
C. VV ECMO
Veno-venous ECMO is designed to provide gas exchange, while veno-arterial ECMO provides both gas exchange and haemodynamic support
CEACCP. Extracorporeal membrane oxygenation in adults.
http://ceaccp.oxfordjournals.org/content/12/2/57 |
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Middle age women c/o pain in hands when hanging out washing. Also found to have muscle wasting on one of the hand associated with weaker radial pulse. * A CRPS
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C. Thoracic outlet syndrome
No best source but seems most likely of options available See CEACCP: Anaesthesia for vascular surgery of the upper limb http://ceaccp.oxfordjournals.org/content/early/2013/09/02/bjaceaccp.mkt044.full.pdf |
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Same radial nerve question with photos of a probe over postero-lateral upper arm and ultrasound image that show a triangular shape nerve, most likely the radial nerve. Injecting 5 ml of 0.75% [[ropivacaine] will produce sensory block over * A Medial forearm* B Lateral forearm * C Dorsum part of hand * D Plantar surface of ring and little finger * E Plantar surface of middle and ring finger |
C Dorsum part of hand |
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Blue urticaria is a complication of * A* B Methylene blue * C Patent blue something * D * E |
C. Patent blue V
Anaphylaxis and blue urticaria associated with Patent Blue V injection http://www.respond2articles.com/ANA/forums/1182/ShowThread.aspx |
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Intraosseous sampling - least accurate on * A Albumin* B Urea * C * D Chloride * E |
Listed options seem to be accurate:
A new study of intraosseous blood for laboratory analysis. http://www.ncbi.nlm.nih.gov/pubmed/20807043
There was a significant correlation between intravenous and IO samples for red blood cell counts and hemoglobin and hematocrit levels but not for white blood cell counts and platelet counts. There was a significant correlation between intravenous and IO samples for glucose, blood urea nitrogen, creatinine, chloride, total protein, and albumin concentrations but NOT for sodium, potassium, CO(2), and calcium levels |
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Subtenon's block - muscle most likely to have inadequate block * A Medial rectus* B Lateral * C Superior * D Superior oblique * E Inferior |
D. Superior oblique
Ophthalmic Regional Block Chandra M Kumar
Most patients develop akinesia with 4 to 5mL of local anaesthetic agent but the superior oblique and eyelid muscles may remain active
http://www.google.com.au/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&ved=0CDMQFjAC&url=http%3A%2F%2Fwww.researchgate.net%2Fpublication%2F7155728_Ophthalmic_regional_block%2Flinks%2F0deec52a5484f135b0000000&ei=vjgtVK-nMs-A8gWXhYCYDg&usg=AFQjCNGEcWQQ31TSfr5oxUkAdYH3HFN29A&sig2=QRCMeJPeGTzktmImvFUvjg |
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In patients with inoperable AS, compared to medical treatment TAVI has significantly lower incidence in 30 days of * A Stroke |
TAVI: 30 day risk of stroke 3% http://www.ncbi.nlm.nih.gov/pubmed/22391581
AF (new onset) 1:3 http://www.ncbi.nlm.nih.gov/pubmed/22177537
Systematic review: http://www.annalscts.com/article/view/1395/2013 The available data on TAVI versus AVR for patients at a higher surgical risk showed that major adverse outcomes such as mortality and stroke appeared to be similar between the two treatment modalities. The indications for TAVI should therefore be limited to inoperable surgical candidates until long-term data become available.
http://circ.ahajournals.org/content/124/3/355.full |
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EVAR, best method to reduce risk of renal impairment * A Sodium bicarbonate |
C. N/Saline
CEACCP. EVAR
Because the EVAR procedure involves the liberal use of contrast media to assist placement and deployment of the graft to ensure proper exclusion of the aneurysmal sac, it is worthwhile ensuring that the patients are well hydrated to prevent postoperative renal impairment. There is no current evidence to support routine use of diuretic agents during EVAR |
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EVAR is preferred over open AAA repair because * A Lower cost
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E. Less crit care
From patient info sheet http://www.ruh.nhs.uk/patients/services/vascular/documents/Endovascular_Aneurysm_Repair_Patient_Information.pdf
Your hospital stay following EVAR is usually about 2 days. You are cared for on a vascular surgical ward and there is usually no need for admission to the Intensive Care Unit. Following open surgical repair you would routinely be admitted to Intensive Care and your overall length of hospital stay would normally be approximately 10 days |
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Laser flex tube with double cuffs - how to inflate cuff(s)? * A Inflate proximal then distal
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A. proximal then distal (see ref below), but some sources infer use of distal cuff if prox cuff ruptures..?E.
http://books.google.com.au/books?id=3U5DAAAAQBAJ&pg=PA160&lpg=PA160&dq=laser+flex+cuff+inflate+both+cuffs&source=bl&ots=Yty1fjgmCl&sig=QtAnUNFKWBOClnTAOCmSdHfehPY&hl=en&sa=X&ei=zA41VOr_FMyA8gXAyYLQDw&ved=0CCcQ6AEwAQ#v=onepage&q=laser%20flex%20cuff%20inflate%20both%20cuffs&f=false
http://www.csen.com/cuff.pdf (search 'laser')
CEACCP laser. http://e-safe-anaesthesia.org/e_library/04/Lasers_and_surgery_CEACCP_2003.pdf "if cuff bursts, second cuff cna be used |
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Forceps delivery. Loss of sensation medial thigh with loss of adduction at hip joint - resulted from injury to * A Sciatic nerve |
D. |
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Called to cath lab because patient became agitated. Unstable angina having PCI,difficult right coronary stenting. Patient was hypotensive 80/40, HR 80/min in SR. What is the next best management step? * A Transfer to operating theater immediately |
D. TTE to exclude tamponade (stem sounds like possible complication - "became agitated", "difficult RCA stenting")
Likely management stay and stabilise.. (therefore B or D) Probably not A (doesn't sound like need to move immediately) or C (needs to be stabilised first). |
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A printout of 12-lead ECG * A Atrial fibrillation with BBB |
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Repeat) Diagram about 3-bottle underwater seal drain, with the height of the fluid level in the suction bottle indicates * A Maximal suction applied to the system |
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Photo of a patient with tongue deviation post cervical spinal fusion. Which nerve is damaged? * A Glossopharyngeal nerve |
C. hypoglossal nerve tongue muscles |
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Post cardiac surgery. Rhythm strip to assess pacing on AOO. What is the diagnosis? * A Pacing spikes with loss of capture |
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Young male with MVA + femur # on traction. More than 24 hours. Became confused and drowsy, BP normal, crackles both lung fields with worsening O2 saturation despite increasing oxygen flow. Diagnosis? * A Fat embolism |
A. fat embolism
(cerebral signs make fat embolism the more likely diagnosis) |
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G5P5 in third stage labour. Found to be unresponsive, cyanosed, faint pulse. On oxytocin induction and epidural infusion 10ml/hour. Also oozing from previous IV or blood sampling sites. Diagnosis? * A High spinal |
B. AFE
(RF for |
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In iron deficiency anaemia, one will expect a serum ferritin level to be less than * A 300mg/L
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Ferritin usually in ng/ml (which is mcg/L) Iron deficiency = <30mcg/L |
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Treatment for patients with congenital long QT syndrome * A Pacemaker/defibrillator |
C. Beta blocker
CEACCP: http://ceaccp.oxfordjournals.org/content/8/2/67.full.pdf
Also emedicine: http://emedicine.medscape.com/article/157826-treatment
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What can not be used for tocolysis in a 30/40 (NOT 34/40) pregnant lady? * A Clonidine
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A. Clonidine (not a tocolytic)
Indomethacin safe until 32 weeks |
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18 month old child with VF arrest, shock with * A 10J
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C. 50J
DC shock in paeds 4J/kg Average 1 yo 10 kg, 2 yo 12 kg
http://www.resus.org.au/public/arc_paediatric_cardiorespiratory_arrest.pdf. |
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Endovascular coiling of cerebral aneurysm under GA, patient suddenly develop hypertension. What is the most likely cause? * A Acute hydrocephalus |
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Ibuprofen dose for children * A 10mg/kg |
A. 10 mg/kg |
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A patient on citalopram. Post-op in PACU given tramadol. Developed fever, tremor, restlessness, confusion, hyperreflexia. Diagnosis is * A Neuroleptic malignant syndrome
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From DSM-IV
Very similar features mostly, differences: serotonin syndrome: hyperreflexia, clonus NMS: hyporeflexia http://www.medsafe.govt.nz/profs/PUArticles/Dec2012Neuroleptic.htm |
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Best drug to reduce both gastric acidity and volume * A Ranitidine
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A. Ranitidine
Na citrate (good for reducing acidity, but may incr volume) |
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Patient on moclobemide came in for surgery. In view of the use of vasopressor to treat hypotension one will give judicious amount of * A |
E. Moclobemide -> MAO inhibitor Avoid indirect action (ephedrine, metaraminol) Use direct acting -> phenylephrine
Peck and Hill ATOTW - Anaesthesia and psych drugs part 1 . |
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Patient with hyperthyroidism - proceed with elective surgery only if normal level of these hormones is seen * A TSH |
D T3 & T4 (TSH will improve later)
See: http://www.sassit.co.za/journals/peri-operative%20care/endocrine/perioperative%20management%20of%20the%20thyrotoxic%20patient.pdf
Ideally, thyrotoxic patients should be as close as possible to clinical and biochemical euthyroidism before going to surgery. It is common for TSH values to remain suppressed as a consequence of prolonged hyperthyroidism in patients who have otherwise normalized their T4 and T3 values on therapy [31]. The TSH level in this case will eventually increase, and should not be considered a contraindication to surgery . |
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In pregnant women the dural sac ends at * A
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D. S1
Nysora: http://www.nysora.com/mobile/regional-anesthesia/sub-specialties/3422-spinal-anesthesia-in-children.html |
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The following capnography trace was observed in an intubated and ventilated patient. The most likely explanation for this respiratory pattern is * A endobronchial intubation |
C. Gas sampling line leak (repeat) |
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Full size oxygen cylinder providing 10L/min of oxygen flow to a patient during transport. How long will this cylinder last? * A
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