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7 Cards in this Set
- Front
- Back
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What are approved treatments for alcohol
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Disulfiram (Antabuse)
Naltrexone (Re Via) Naltrexone IM (Vivitrol) Acamprosate (Campral) |
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Disulfiram (Antabuse)
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250mg qd
Blocks aldehyde dehydrogenase leading to toxic levels acetaldehyde SE flushing, vomiting, hypotension Need to be highly motivatednal |
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Naltrexone (Re Via) (Vivitrol)
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FDA alcohol dependence and opioids
Po 50mg qd (start 25mg 2 days for opioid dependance) IM 380mg q4weeks Pt needs to be opioid free for 7-10days as confirmed by urine tox SE nausea, dizziness, abdominal pain and site reaction; hepatotoxicity in excessive doses D/d not Cyp450 Caution that pt may need less opioids or they overdose |
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Advantages of naltrexone
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Increases abstinence and harm reduction drinking
Reduced risk Man 3-4 drinks per day tot 16 per week Women 2-3 12 per week |
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Acamprosate (Campral)
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FDA maintenance of alcohol abstinence
Acts as "artificial alcohol" to decrease glutamate activity and increase GABA activity in the absence of alcohol SE diarrhea, nausea, anxiety, depression 666mg tid (333mg tab) |
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Nicotine patch
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Pack per day
21mg for 6 wks 14mg 2week 7mg 2weeks 1/2pack 14mg 6 weeks 7mg 2 weeks |
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Varenicline (Chantix)
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Set quit date. Start 1week before. 0.5mg 3 days 0.5mg bid 4days 1mg bid w FOOD agonist at nicotine receptors small DA release in nucleus accumbens SE nausea, flatulance, constipation, insomnia, headache, abnormal dreams CAUTION monitor behavioral changes, agitation, suicidality and depression. Monitor other drug dosages 1A2 |
