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8 Cards in this Set
- Front
- Back
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Types of TCAs
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1. Imipramine
2. Amitriptyline 3. Trimipramine 4. Nortriptyline - doesn't cause orthostatic hypoTN 5. Desipramine - fewest anticholinergic effects 6. Clomipramine - most 5HT specific, good for OCD 7. Doxepin |
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Side effects of TCAs (6)
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1. Antihistamine (sedative)
2. Antiadrenergic 3. Antimuscarininc 4. Weight gain 5. Lethal in OD 6. 3C's: Convulsions, coma, cardiotoxicity (widened QRS >100msec) |
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Side effects of MAOI's
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Common: Orthostatic HypoTN, drowsiness, wt gain, sexual dysfxn, dry mouth, sleep dysfxn
Serotonin Syndrome if SSRI + MAOI together Hypertensive Crisis - MAOI + tyramine |
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Side effects of SSRI's
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1. Sexual dysfunction
2. GI disturbance 3. Insomnia 4. HA 5. Anorexia, wt loss 6. Serotonin syndrome w/ MAOI |
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5HT + NE Reuptake Inhib - SNRI: Venlafaxine
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Good for treating refractory depression + CAP
Can raise BP S/E sim to SSRI |
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NE + DA Reuptake Inhib - NDRI: Bupropion
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Lack of sexual side effects
Risk of increased sweating, seizures, and psychosis |
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5HT Antag + Reuptake Inhib - SARI: Nefazodone or Trazodone
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Good for refractory depression, depression w/ anxiety, insomnia
S/E: nausea, dizziness, orthoHypoTN, arrhythmias, sedation, priapism |
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NE + 5HT Antag - NASA: Mirtazapine
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Refractory MDD in pts that need to gain wt. Max sedative effect at <15mg
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