Among many inherited disease there is a disorder called hemophilia. Hemophilia is a bleeding disorder that is a result of different problems in the blood coagulation pathway. Being unable for the blood to clot results in prolonged bleeding even after minor procedures such as pulling a tooth. In the most sever cases bleeding can happen spontaneously. This disorder can lead to complications from bleeding in areas such as the brain, muscles, and other internal organs, and may also lead to death. This disease can be caused by mutations on two different genes, therefore producing two types of hemophilia. The mutations occur on the long arm (q) of the x chromosome, making this an sex-linked disease. The changes in F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. Both these genes are involved in the coagulation factors. Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. Normally only males inherit this disease. Carrier females have about half the usual amount of coagulation factor VIII or coagulation factor IX, which is generally enough for normal blood clotting. Being able to test for this genetic disease at early stages of pregnancy can help a couple decide if they want to bring to life a child that with this condition, or perhaps make an
Among many inherited disease there is a disorder called hemophilia. Hemophilia is a bleeding disorder that is a result of different problems in the blood coagulation pathway. Being unable for the blood to clot results in prolonged bleeding even after minor procedures such as pulling a tooth. In the most sever cases bleeding can happen spontaneously. This disorder can lead to complications from bleeding in areas such as the brain, muscles, and other internal organs, and may also lead to death. This disease can be caused by mutations on two different genes, therefore producing two types of hemophilia. The mutations occur on the long arm (q) of the x chromosome, making this an sex-linked disease. The changes in F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. Both these genes are involved in the coagulation factors. Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. Normally only males inherit this disease. Carrier females have about half the usual amount of coagulation factor VIII or coagulation factor IX, which is generally enough for normal blood clotting. Being able to test for this genetic disease at early stages of pregnancy can help a couple decide if they want to bring to life a child that with this condition, or perhaps make an