Using Inhaled Drugs, Clinical Pharmacists And Theophylline And Higher Doses May Be Required

1493 Words Jan 18th, 2016 6 Pages
F patients, it may lead to a decrease in the bioavailability of theophylline and higher doses could be required. Secondly, theophylline is metabolised in the liver via cytochrome P450, as a result it involves in a lot of drug interactions. Therefore, monitoring by a clinical pharmacist is necessary with this medication (Dipiro et al., 2008). Additionally, when using inhaled drugs, clinical pharmacists can assist in determining a number of factors such as if it is suitable to give inhalers as a combination, which inhaler can be given with the others and which cannot (Kerem, Conway, Elborn & Heijerman, 2005).
Mucolytic Therapies, such as dornase alfa and hypertonic saline, are also used to decrease sputum viscosity and enhance clearance. However, some individuals cannot tolerate high concentrations of hypertonic saline. As a result, individualised concentration may be required (Benavides et al., 2013). Moreover, pharmacists must make sure that the hypertonic saline is not mixed with other nebuliser; otherwise, the resulting osmorlaity would be altered (DiPiro et al., 2008).
Anti-inflammatory medication includes inhaled and systemic corticosteroids, high dose ibuprofen as well as azithromycin. The use of systemic corticosteroids is not recommended long-term, because of the adverse effects. Moreover, the use of low dose ibuprofen might increase inflammation. Accordingly, higher doses are necessary to target the needed plasma level (Chisholm-Burns et al., 2013). Yet, because of…

Related Documents