Types Of Basal Cell Carcinoma Essay example

808 Words Apr 22nd, 2016 4 Pages
Background
Basal cell carcinoma can be defined as a malignant neoplasm in humans. Basal cell carcinoma originates in the areas between the follicles, subject to a spontaneous mutation. BCC’s can be organized into four categories: nodular, morpheaform, metatypical, and superficial. BCC can be treated generally through SMO inhibitors, for example, vismodegib (Ximena 398). Vismodegib is a molecule inhibitor of the Hedgehog (Hh) pathway (Pricl 389). The pathogenesis of BCC is the inapposite activation of the Hh pathway. A molecule on the Hh pathway binds to the receptor on the PTCH1 resulting in inactivation, which then prevent the inactivation of the SMO receptor (Pricl 390). The two main signaling pathways that are most often affected in tumor cells include as mentioned above, as well as alterations in the TP53 (Ximena 398). The authors believe that there are other unknown genes involved due to the inconsistency in the tumors, even with the knowledge of the most common driver pathway. These inconsistencies entail differences in aggressiveness of the tumors, morphology, and the response to treatment (Ximena 398). The authors hypothesized that other genes and pathways to take into account in the contribution to BCC formation and progression (Ximena 398)
Methods
In the experiment a total of 236 patients with a mutational screen of 293 BCC’s, with only 225 BCC’s accumulated for this experiment, also 68 previously sequenced data from reported cases were included. From these…

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