Alzheimer's disease (AD) is an irreversible, progressive brain disorder, which is the most widely recognized symptoms of dementia and it is degenerative disorder of the brain that leads to memory loss. AD is mainly responsible for the deposition of β-amyloid peptides that are formed by the action of sequential cleavage of β-amyloid precursor protein (APP). The two types of amyloid beta formed from secretase cleavage are Aβ40 and Aβ42, with the latter being the prevalent form found in the senile plaques. Blocking the activity of beta-secretase 1 or γ-secretase can inhibit the production of Aβ peptidase. Ultimately, subsequent oxidative stress and biochemical changes result in the neuronal death and neuritic plaques growth of AD, which makes
