Essay about Symptoms And Treatment Of The Gout Syndrome
1. Decreased excretion (underexcretors): Accounts for most cases and occurs when altered uric acid excretion results from decreased glomerular filtration (can contribute to the hyperurecemia of renal insufficiency), decreased tubular secretion (seen in patients with acidosis when accumulated organic acids compete with urate for tubular secretion), or enhanced tubular reabsorption (when distal to the site of secretion, thought to be responsible for hyperuricemia observed with diuretic therapy and diabetes insipidus) .
2. Increased production (overproducers): Occurs in a small number of patients and is caused by diets rich in purines (liver, kidney, meat gravies, broths, sardines, sweetbreads) or increased purine nucleotide breakdown. It can also be caused by increased nucleoprotein turnover in hematologic conditions (lymphoma, leukemia, hemolytic anemia) and in conditions with increased rates of cellular proliferation and cell death (cancer and radiation therapy).
3. Combination of increased…