Schiff Base Essay

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CHAPTER 2

LITERATURE REVIEW

2.1 Synthesis of Schiff base
Method preparation for Schiff base ligand is a straight forward synthesis and easily modified using different amines and carbonyl compound. This could be one of the reasons that make Schiff base ligand popular in coordination chemistry research. Synthesis of Schiff base ligand commonly, taking place in alcohol through condensation reaction of amines and carbonyl compound. The acid/base catalysis or heating is employed in the synthesis of Schiff base as their reactions are mostly reversible ((Mishra N. et al, 2013).
Aly M.H. et al, 2015 reported the synthesis of Copper (II) complexes with 1,2,4-triazole Schiff bases. The Schiff base compound prepared from condensation reaction
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et al, (2015). The anti-bacterial activities of Schiff base and new compound have been test in-vitro against gram three gram negative bacteria (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Acinetobacterbaumannii RSKK 02026), three gram positive bacteria (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 07005, Bacillus subtilis ATCC 6633) Ӧzdemir Ӧ. et al, (2015 ). They have reported that all compound show mild to moderate activity against gram negative bacteria but more active in gram positive bacteria. Figure 2.3.3 and Figure 2.3.4 are the tabulation data for the screening of anti-bacteria activities of the Schiff base against gram positive and gram negative bacteria. Figure 2.3.3 Screening for anti-bacteria activities against gram positive bacteria

Figure 2.3.3 Screening for anti-bacteria activities against gram negative bacteria
Hasi Q. et al, (2016) reported the studies on preparation of Mn(III) and Cu(II) complexes based on bis(N-(3-methoxy-salicylidene)-4-amino-phenyl)ether (H2L). Anti-bacterial activities of metal complex and its ligand are studies against gram-positive Bacillus subtilis and gram-negative Escherichia coli by the filter paper diffusion method. The different metal complex with same ligands is use on similar microorganism. Cu(II) complexes exhibit excellent activity compare to Mn(III) complexes and its ligand.

2.4 Previous study on Schiff bases as

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