Pros And Cons Of Cyclophosphamide

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• The mechanism of action of cyclophosphamide is an alkylating agent that causes cross-linkage of DNA strands, thereby blocking synthesis of DNA, RNA, and protein. Has pronounced antineoplastic effects and immunosuppressive activity. EFFECTS??
• The Pharmacodynamics of the cyclophosphamide includes the absorption from the GI tack. The drug is widely distributed going to the brain, and breast milk. Should be careful while taking cyclophosphamide because it does cross the placenta. The drug Metabolizes in the liver by Cytochrome P450 3A4 (abbreviated CYP3A4). The drug is eliminated through the urine as active metabolites and unchanged drug. Peak of the drug is one hour taken orally. The drug has a half-life of four to six hours.
• Potential adverse effect of
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Hair loss may begin three weeks after therapy begins. Regrowth of the hair starts five to six weeks after the drug is withdrawn and may occur while on maintenance dose. Amenorrhea may last up to one year after cessation of therapy in 10-30% of women. Do not omit, decrease, increase, or delay dose. If there is any reason that you cannot take the drug notify your prescriber. Use contraception during the use of the drug and for at least four months after termination of the drug treatment. Breast-feeding should be discontinued before the use of cyclophosphamide therapy is given. Instruct patient to notify health care professional promptly if fever; sore throat; signs of infection; lower back or side pain; difficult or painful urination; sores in the mouth or on the lips; yellow discoloration of skin or eyes; bleeding gums; bruising; petechia; blood in urine, stool, or emesis; unusual swelling of ankles or legs; joint pain; shortness of breath; cough, palpitations, weight gain of more than 5 lbs in 24 hrs dizziness, loss of consciousness or confusion

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