Ethnopharmacological relevance: Aerial parts of Nasturtium officinale R. Br. are used traditionally in Iran as a folk medicine in different illnesses which include bronchitis, asthma, diabetes, hypertension, and renal colic.
Aim of the study: In the present study, the anti-inflammatory activity of hydro-alcoholic extract from aerial parts of N. officinale was investigated in acute and sub¬¬-acute models of inflammation.
Materials and methods: Different models like carageenan induced hind paw edema in rats, formalin induced paw edema in rats and 12-O-tetradecanoylphorbol-13-acetate (TPA) evoked ear edema in mice were used for studying the anti-inflammatory …show more content…
Nasturtium officinale R. Br. (Watercress), from Brassicaceae family, is found in the most regions of the world and Iran. The leave of this plant has been traditionally used as a home remedy to treat hypertension, diabetes, asthma and renal colic in Iranian folkloric medicine and is usually eaten in fresh form as a vegetable in salads, soups and other recipes. Watercress is known to have several pharmacological effects such as potent anti-oxidant activity, anti-hyperlipidemia (Bahramikia (2010) (Yazdanparast et al. (2008), hypoglycemia (Menczel, 1963; Ribes et al., 1986; Sharma, 1986; Sharma et al., 1990), anti-ulcerogenic (Alkofahi A., Atta A.H.: J. Ethnopharmacol. 67, 341 (1999), anticarcinogenic, antiestrogenic activity (Tamayo C., Richardson M.A., Diamond S.,Skoda I.: Phytother. Res. 14, 1 (2000), digestive aid and nutritional supplement (Sezik E., Yesiladag E., Honda G., Takaishi Y., Takeda Y., Tanaka T.: J. Ethnopharmacol. 75, 95 (2001)), appetite stimulation (Bouaziz, 1976; Petit et al., 1993), laxation (Riad and El-Baradie, 1959), fungicide (Clifton and Husa, 1954) and treatment of lung and other cancers in humans (Kellof G.J., Boone C.W., Crowell J.A.,: J. Cell. Biochem. 26, 1 …show more content…
officinale in acute and sub-acute models of inflammation.
2. Materials and methods
2.1. Plant material
Aerial parts of N. Officinale were collected from Yasuj, Iran at the end of spring 2012 and authenticated by Dr. A. Jafari (Department of Botany, Center for Research in Natural Resource and Animal Husbandry, Yasuj University, Yasuj, Iran) and a voucher specimen (Herbarium No. HYU30230) was deposited there. The aerial parts of plant were air-dried and protected from direct sunshine.
2.2. Preparation of plant extract
The well powdered plant parts (300 g) were extracted two-times with l000mL mixture of EtOH-H2O (7:3) at 45 °C for 48 h. The extract was filtered and organic solvent was completely evaporated under reduced pressure in a rotary evaporator at 60 °C. Then, the concentrated extract was dried at room temperature. The average yield ratio of the ethanol extract was approximately 20.5%. 2.3. Experimental