During high-intensity exercise, the intramuscular accumulation of lactic acid has long been considered one of the most important factors in fatigue (Fitts RH.1994; Green HJ 1997; Allen DG,1995; Gladden LB.2004;Sahlin K.1986). Intense physical activity results in the production of lactate, and the accumulation of lactate in exercising muscle is thought to be a major determinant of fatigue (Hermansen L, Osnes J.1972; Stamford BA,1981).
2.1 Mechanism of muscle fatigue due to lactic acid
Most researchers have argued that any detrimental effects of HLa on muscle and exercise performance are due to H+ rather than La− (Fitts, 2003, Hinzpeter.J,2014). There is a vast literature in which a decline in maximal muscle force generation is correlated …show more content…
Acute accumulation of BLa can induce metabolic acidosis which sequentially can decrease the work capacity of a person’s muscles leading to a decrease in performance (Myers J, Ashley E (1997);Neric et al.,(2009). Force production recovers almost fully while muscle pH remains depressed during recovery, suggesting that the high [H+] may indirectly affect performance by impairing energy metabolism (Sahlin, K, …show more content…
2004); (ii) an increase in lactate elimination from the muscle; (iii) lactate transportation to other tissues (liver, heart, muscles) where it can be oxidized or used as a substrate for glucose resynthesis; or (iv) a combination of these 3 factors (Gollnick et al. 1986; Neric et al. 2009). Several studies have suggested that maintaining a level of activity, even low, generates oxidative activity, which may decrease the lactate available for glycogen resynthesis (Choi et al. 1994; Fairchild et al. 2003). During recovery, the decrease in blood lactate concentration is generally associated with a decrease in H+ concentration causing a return to higher pH values and HCO3 – concentrations both in the blood and the active muscle (Yoshida et al. 1996) .Recovery methods limit the negative effects linked to accumulation of H+ ions and decreased pH, which commonly affect the contractile process during repeated performances (Fitts
2.1 Mechanism of muscle fatigue due to lactic acid
Most researchers have argued that any detrimental effects of HLa on muscle and exercise performance are due to H+ rather than La− (Fitts, 2003, Hinzpeter.J,2014). There is a vast literature in which a decline in maximal muscle force generation is correlated …show more content…
Acute accumulation of BLa can induce metabolic acidosis which sequentially can decrease the work capacity of a person’s muscles leading to a decrease in performance (Myers J, Ashley E (1997);Neric et al.,(2009). Force production recovers almost fully while muscle pH remains depressed during recovery, suggesting that the high [H+] may indirectly affect performance by impairing energy metabolism (Sahlin, K, …show more content…
2004); (ii) an increase in lactate elimination from the muscle; (iii) lactate transportation to other tissues (liver, heart, muscles) where it can be oxidized or used as a substrate for glucose resynthesis; or (iv) a combination of these 3 factors (Gollnick et al. 1986; Neric et al. 2009). Several studies have suggested that maintaining a level of activity, even low, generates oxidative activity, which may decrease the lactate available for glycogen resynthesis (Choi et al. 1994; Fairchild et al. 2003). During recovery, the decrease in blood lactate concentration is generally associated with a decrease in H+ concentration causing a return to higher pH values and HCO3 – concentrations both in the blood and the active muscle (Yoshida et al. 1996) .Recovery methods limit the negative effects linked to accumulation of H+ ions and decreased pH, which commonly affect the contractile process during repeated performances (Fitts