Globus Pallidus

inhibited by the increase activity at the globus pallidus internus (Lundy-Ekman, 2013).

The disease involves a change in the basal ganglia motor circuit. The motor

circuit consists of sending output information to the cerebral cortex , pedunculopontine

nucleus and the midbrain locomotor area. The direct pathway consists of the the substantia

nigra via the nigrostriadal pathway sends dopamine cells that are excitatory to the globus

pallidis internus . The globus pallidus is inhibited creating disinhibition of the thalamus and

excitory neurons are sent to the motor cortex. The result is facilitation to the lower motor

neurons that innervate the voluntary muscles. In the indirect pathway the dopamine acts

as a inhibitory