Extraction and Evaporation: Separating the Components of "Panacetin"

1226 Words Jul 3rd, 2012 5 Pages
Extraction and Evaporation: Separating the Components of "Panacetin"
Submitted- July 17, 2012 Introduction The purpose of this lab is to investigate the composition of a compound suspected to be Panacetin, a type of pain-killer. Panacetin is typically made up of sucrose, aspirin, and acetaminophen, but the third component in this experiment is unknown. The unknown component is suspected to be a chemical relative of acetaminophen, either acetanilide or phenacetin. Using techniques such as extraction, evaporation, and filtration, the three components will be isolated based on their solubilities and acid-base properties. Then, the percent composition of Panacetin can be deduced based on the masses of the three dried components. The
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After centrifugation to isolate the sucrose, sucrose appeared to be crystalized on the bottom of the tube, while the aspirin, unknown, and dichloromethane were an aqueous layer on top. Separation of Aspirin: Sodium bicarbonate was added to the aqueous solution in Tube B. A slight fizzing occurred as a result of the release of carbon dioxide. The solution then separated into two separate layers. When HCl was added, the aqueous solution fizzed. Separation of the Unknown: When concentrating the unknown component by evaporation, it took roughly five minutes to form a solid. Figure 3. The Reaction with Aspirin and Sodium Acetylsalicylate

Caption: This shows the reaction between aspirin and sodium bicarbonate to form a salt called sodium acetylsalicylate, with by-products of water and carbon dioxide.

Discussion Panacetin is known to be composed of three different components: sucrose, aspirin, and an unknown, which is either acetanilide or phenacetin. It was expected to contain 10% sucrose, 50% aspirin, and 60% of the unknown. To find the composition of the 0.4015 g Panacetin, techniques of centrifugation, extraction, and evaporation were used to isolate and study the different components. When dichloromethane was added to the Panacetin and then centrifuged using a Fischer Scientific Centrific 228, it was observed that a solid sucrose pellet had

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