Causes And Treatment Of Periodontal Disease Essay

985 Words Dec 14th, 2015 4 Pages
Abstract: Periodontal disease affects the majority of the population and is the second most common dental disease worldwide. Infection arises from plaque that is formed when starches and sugars in food interact with the bacteria normally found in the mouth. Plaque can lead to tarter and eventually can result to severe irritation and inflammation of the gingivitis. Ongoing inflammation creates pockets that accumulate with bacteria, resulting in the recession of the periodontium and the progressive loss of alveolar bone. A potential target for inhibiting bone resorption is the protein Developmental Endothelial Locus-1 (Del-1). Del-1 is able to function as an anti-inflammatory by blocking excessive immune cell infiltration into the periodontium and also has an innate anti-osteoclastogenic activity by being able to inhibit bone loss by interrupting the signaling pathways to osteoclastogenesis. In vitro and in vivo studies were done that demonstrated Del-1’s upstream mechanism in disease signaling pathways to prevent inflammatory cell recruitment to the teeth and gums as well as its downstream mechanism in inhibiting osteoclastogenesis. This provides a promising advancement in a potential periodontal disease treatment. This in turn can help patients prevent development of other systemic diseases associated with periodontal disease.
Underlying Mechanisms of Del-1 and Its Potential Clinical Implications for Treatment of Periodontal Diseases
Periodontal disease, or periodontitis,…

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