Causes And Treatment Of Liver Fibrosis Essay

1572 Words Oct 4th, 2016 7 Pages
Liver fibrosis is a leading cause of morbidity and mortality worldwide which is usually associated with chronic liver disease. Liver fibrosis may develop into cirrhosis within 1–10 years [1]. Hence, blocking the progression of fibrosis may be an effective strategy for survival. This current study is designed to assess the anti-oxidant, antifibrotic and anti-inflammatory potentials of Sitagliptin, Silymarin, and their combination in the CCL4-induced liver fibrosis in rats. Many researchers have used liver hepatic enzymes as useful hallmarks of CCl4 hepatotoxicity [2]. The CCL4 intoxication characterized by a significant increase in the biochemical markers of liver injury (ALT, AST, ALP and γ-GGT). These attributed to hepatic structural damage because these enzymes are localized to the cytoplasm and released into the circulation after cellular and mitochondrial damaged (3). Another marker of liver injury is γ-GGT, which is an enzyme catalyzing the first step in GSH degradation [4]. Increases in serum γ-GGT as observed in CCl4 group can lead to an overproduction of free radicals and decrease GSH level [5]. In the current study, CCL4 treated rats showed a significant increase of hepatic marker enzymes [6]. Our data showed that the administration of Sitagliptin (DPP4-I) showed a significant improvement of hepatic marker enzymes, the results of sitagliptin are in agreements with other recent studies [7-9]. It is shown that DPP4 inhibitors ameliorated the abnormality…

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