Benzodiazepines Case Studies

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Biologically, benzodiazepines bind to GABA receptor sites in the brain. GABA is an important inhibitory neurotransmitter that if in excess amounts in the brain or regulated can cause seizures and sleep problems respectively.
Previously, scientists have tried medication substitution to anxiolytics, agonist substitution to mimic the effect, or abstain completely. Liebrenz and his team of five scientists suggest that, “patients’ subjective views are of clinical importance because past research indicates that individuals should be presented with a variety of treatment alternatives, rather than simply being informed about what is obtainable or easiest; in addition, this prior research has found interventions to be most beneficial when patients
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2). Thus, the objective and the purpose of his experiment was to comprehend the treatment approach as well as participants being open minded to alternative treatments to the current methods of care. The experiment was conducted at the Psychiatric University Hospital of Zurich which was a qualitative study aimed at patients for treatment strategies and withdrawal treatment. The sample of participants was obtained by purposeful sampling and saturation sampling. These methods of sampling ensured that everyone in the experiment was a viable candidate for testing. There were a total of 41 participants, 31 male and 10 female. Each told the doctors their duration of use of their benzodiazepine, initial age of benzodiazepine use, and the maximum dosage that they administered themselves, regardless of if it was for recreational or medical use. In the study, 71% of BZD users wanted to stop taking the drug as they believed it was detrimental to their productivity and overall happiness as an adult. Patients with high dose benzodiazepine dependence were in favor of tapering treatment rather than discontinuation of taking the drug. One of the major concerns of tapering is suffering relapse, or a period of detriment after a …show more content…
Flumazenil is GABA receptor antagonist, which means it blocks certain neurochemicals from benzodiazepines from reaching receptor sites in the brain, thus stopping the effect of benzodiazepines (Moore, 2014, p. 127). Similarly to tapering less powerful types of benzodiazepines, flumazenil would be administered via injection in lowering dosages over time to slowly help the patient gain independence from benzodiazepines. Because the half-life, or time that the drug is active in one’s bloodstream, “it improves the level of consciousness in patients with benzodiazepine overdose; however, resedation may occur within one to two hours after administration, so repeated doses or a continuous infusion may be required to maintain therapeutic efficacy” (Hoffman, 1993, p. 803). Despite the constant administration of flumazenil, it is not addictive, thus allowing it to be administered

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