Anaphylaxis And The Emergency Department Essay

1153 Words Oct 27th, 2015 5 Pages
Anaphylaxis in the Emergency Department
Anaphylaxis is a hypersensitivity reaction and can start immediately after a trigger. Anaphylaxis is common in the emergency department and is considered a medical emergency when symptoms are present. This disorder does not discriminate when it comes to age, gender or race. Reactions commonly occur due to medications, insect stings, aeroallergens and food allergies. This disorder can progress rapidly with multiple reactions throughout the body. Without medical intervention of severe reactions, death can occur. Anaphylaxis can cause contraction of bronchial smooth muscle, laryngeal edema, and vascular collapse which may result in respiratory distress, decreased blood pressure and shock (McCance & Huether, 2014).
Pathophysiology
Anaphylaxis is an acute, multisystem syndrome resulting from the sudden release of mast cell- and basophil-derived mediators into the circulation (Sampson, 2006). Once the body is exposed to an allergen/antigen, antigen presenting cells (ACPs) interacted with other cells in the body. The ACPs will mark the cell so that other cells will recognize it, T-cells and B-cells. Production of mast cells, IgE antibodies, and IgE receptors is induced by a cellular response to the antigen (McCance & Huether, 2014). This will lead to the production of IgE antibodies. IgE antibodies will enter the blood stream and then circulate throughout the tissues. IgE antibodies will bind to receptors that are located on the surface of…

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