Essay on A Short Note On The Pathophysiology Of Asthma

988 Words Sep 3rd, 2016 4 Pages
The pathophysiology of Asthma is characterized by the pathological changes in the submucosal glands, the increase of smooth muscle composition and hardening of the lamina reticularis; due to the recurrent inflammation and over production of mucus in the airways (Holgate & Sly, 2014). The inflammatory response is highly associated with the clinical symptoms of wheezing, coughing, short of breath and chest tightness (Cosio, Rosado & Rossi, 2012). This response is triggered by common risk factors which can be known as environmental exposures (e.g. tobacco smoking or exposure), Toxins (e.g. pollutants in the air), viral infections (e.g. respiratory infections) and others such as allergens (e.g. dust), stress, exercise and dietary changes (Mims, 2015).

Patients that are diagnosed with asthma will over secrete in the production of mucus, due to the inflammatory and immunologic responses to environmental triggers. The immunologic antibody IgE plays a vital role in attaching to the trigger, causing a reaction which signals the eosinophils, neutrophils and T lymphocytes in the circulation to the airways (Holgate & Sly, 2014). In conjunction, the Resident cells such as the alveolar macrophages and the mast cells, are mediators that trigger an allergic reaction response to environmental triggers, which live in the alveoli (Holgate & Sly, 2014). The immunologic antibody IgE attaches to the trigger and signals the mast cells to attach to the IgE, where soon after it then releases the…

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