2.3.3 Regulation of blood flow
The normal functionig of the brain is dependent on the relation between cerebral blood flow (CBF) and the needs of neuronal metabolism. It means, that the most active neurons would need increased blood flow in the tissues around them. This phenomenon is also known as hyperemia. Since astrocytes play a supporting role to neurons and form networks with blood vessels across CNS , it is also believed that they are primary mediators that influences the local blood flow in response to neuronal activity [17]. As recent studies suggest, astrocytes produce and release high numbers of different type mediators, such as nitric oxide (NO), arachidonic acid (AA), prostaglandis (PGE) that can increase or decrease the blood
The normal functionig of the brain is dependent on the relation between cerebral blood flow (CBF) and the needs of neuronal metabolism. It means, that the most active neurons would need increased blood flow in the tissues around them. This phenomenon is also known as hyperemia. Since astrocytes play a supporting role to neurons and form networks with blood vessels across CNS , it is also believed that they are primary mediators that influences the local blood flow in response to neuronal activity [17]. As recent studies suggest, astrocytes produce and release high numbers of different type mediators, such as nitric oxide (NO), arachidonic acid (AA), prostaglandis (PGE) that can increase or decrease the blood