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10 Cards in this Set
- Front
- Back
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Define seronegative spondyloarthropathies (genetic associations and epidemiology)
Name the 3 diseases in this category |
Arthritis without RF
Strong association with HLA B27 (codes for MHC I) Occurs more in males Anklyosing spondylitis, Reiter's syndrome, Psoriatic arthritis |
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Signs/symptoms of ankylosing spondylitis
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Chronic inflammatory disease of spine and sacryoiliac joints; stiff spine due to fusion of joints; uveitis and aortic regurgitation seen; bamboo spine on x ray
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Associations of anklyosing spondylitis
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Inflammatory bowel disease
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Classic triad of Reiter's syndrome
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(1) conjunctivitis and anterior uveitis
(2) urethritis (3) arthritis |
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Possible causative agent to Reiter's?
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Chlamydia
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Psoriatic arthritis presentation
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Joint pain and stiffness associated w/psoriasis; asymmetric and patchy involvement
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X ray signs of psoriatic arthritis
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Dactylitis (sausage fingers)
"pencil in a cup" |
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Why do SLE patients have false positives on RPR/VDRL syphilis tests?
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Antiphospholipid antibodies cross react w/cardiolipin used in tests
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Autoantibodies in SLE and their significance
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(1) ANA (sensitive, not specific)
(2) anti dsDNA (very secific, poor prognosis) (3) anti-Smith (very specific but not prognostic) (4) antiHistone (drug induced lupus) |
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Systemic lupus presentation
I'M DAMN SHARP |
Ig's (anti dsDNA, anti-Sm, andphospholipid)
Malar rash Discoid rash ANA Mucositis (oropharyngeal ulcers) Neurological disorders Serositis (pleuritis, pericarditis) Hematologic disorders Arthritis Renal disorders Photosensitivity |
