P1:
Ankylosing spondylitis, or AS, is a chronic inflammatory autoimmune disease of the axial skeleton with a strong link to genetics, which mainly effects the joints of the spine and the sacroiliac joints of the pelvis. The strong genetic links sit with the HLA-B27 gene which has unusual properties in those with AS, and there is evidence to suggest that it may interact with the T cell receptors in association with CD4. Evidence suggests that AS has association with, not only the HLA-B27 gene, but also TNF α, Il-1, and anti-neutophil cytoplasmic antibodies or ANCAs; however these do not determine severity of the condition. Progression of AS 1 Found: http://www.webmd.com/arthritis/ankylosing-spondylitis
The main changes to the body for an …show more content…
However, opioid based painkillers can cause drowsiness, loss of thought and nausea effecting the day-to-day life of those prescribed these drugs. As previously discussed AS has strong genetic links, however there are many individuals who suggest that diet, specifically one high in starch, and exercise may play a crucial role in the development of AS, however there is only inconclusive evidence to support this. Malnutrition and a sedentary life style may not cause AS directly, but can affect the severity of the disease, with regular exercise being suggested as a type of treatment for those with …show more content…
X-ray diagnosis is unreliable because the signs of AS have to have been established for 8-10 years before they may show up on a regular film X-ray. There are options for earlier diagnosis such as MRI scans and tomography scans, however the reliability of these tests is yet to be determined. Furthermore, blood test may also be used as people with AS may show and increase in the blood concentration of C-reactive protein and an increase in the erythrocyte sedimentation rate; blood test are unreliable the increase in the CPR and ESR are not seen in every patient with AS. Moreover, a genetic test can help diagnose AS if the HLA-B27 gene is present, however it cannot directly diagnose a patient with
Ankylosing spondylitis, or AS, is a chronic inflammatory autoimmune disease of the axial skeleton with a strong link to genetics, which mainly effects the joints of the spine and the sacroiliac joints of the pelvis. The strong genetic links sit with the HLA-B27 gene which has unusual properties in those with AS, and there is evidence to suggest that it may interact with the T cell receptors in association with CD4. Evidence suggests that AS has association with, not only the HLA-B27 gene, but also TNF α, Il-1, and anti-neutophil cytoplasmic antibodies or ANCAs; however these do not determine severity of the condition. Progression of AS 1 Found: http://www.webmd.com/arthritis/ankylosing-spondylitis
The main changes to the body for an …show more content…
However, opioid based painkillers can cause drowsiness, loss of thought and nausea effecting the day-to-day life of those prescribed these drugs. As previously discussed AS has strong genetic links, however there are many individuals who suggest that diet, specifically one high in starch, and exercise may play a crucial role in the development of AS, however there is only inconclusive evidence to support this. Malnutrition and a sedentary life style may not cause AS directly, but can affect the severity of the disease, with regular exercise being suggested as a type of treatment for those with …show more content…
X-ray diagnosis is unreliable because the signs of AS have to have been established for 8-10 years before they may show up on a regular film X-ray. There are options for earlier diagnosis such as MRI scans and tomography scans, however the reliability of these tests is yet to be determined. Furthermore, blood test may also be used as people with AS may show and increase in the blood concentration of C-reactive protein and an increase in the erythrocyte sedimentation rate; blood test are unreliable the increase in the CPR and ESR are not seen in every patient with AS. Moreover, a genetic test can help diagnose AS if the HLA-B27 gene is present, however it cannot directly diagnose a patient with