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64 Cards in this Set
- Front
- Back
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Define seronegative spondyloarthropathies (genetic associations and epidemiology)
Name the 3 diseases in this category |
Arthritis without RF
Strong association with HLA B27 (codes for MHC I) Occurs more in males Anklyosing spondylitis, Reiter's syndrome, Psoriatic arthritis |
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Signs/symptoms of ankylosing spondylitis
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Chronic inflammatory disease of spine and sacryoiliac joints; stiff spine due to fusion of joints; uveitis and aortic regurgitation seen; bamboo spine on x ray
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Associations of anklyosing spondylitis
|
Inflammatory bowel disease
|
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Classic triad of Reiter's syndrome
|
(1) conjunctivitis and anterior uveitis
(2) urethritis (3) arthritis |
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Possible causative agent to Reiter's?
|
Chlamydia
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Psoriatic arthritis presentation
|
Joint pain and stiffness associated w/psoriasis; asymmetric and patchy involvement
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X ray signs of psoriatic arthritis
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Dactylitis (sausage fingers)
"pencil in a cup" |
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Why do SLE patients have false positives on RPR/VDRL syphilis tests?
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Antiphospholipid antibodies cross react w/cardiolipin used in tests
|
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Autoantibodies in SLE and their significance
|
(1) ANA (sensitive, not specific)
(2) anti dsDNA (very secific, poor prognosis) (3) anti-Smith (very specific but not prognostic) (4) antiHistone (drug induced lupus) |
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Systemic lupus presentation
I'M DAMN SHARP |
Ig's (anti dsDNA, anti-Sm, andphospholipid)
Malar rash Discoid rash ANA Mucositis (oropharyngeal ulcers) Neurological disorders Serositis (pleuritis, pericarditis) Hematologic disorders Arthritis Renal disorders Photosensitivity |
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Sarcoidosis associations
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Gammaglobulinemia
RA ACE increase Interstitial fibrosis Noncaseating grabulomas |
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Why is hypercalcemia seen in sarcoid
|
Elevated conversion of vitD to its active form in epithelioid macrophages
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Signs/sx of sarcoidosis
|
Restrictive lung disease
Erythema nodosum Bell's palsy Hypercalcemia Uveoparotitis |
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Polymyalgia rheumatica symptoms
|
Pain and stiffness in shoulder and hips, often with fever, malaise, wt loss
No muscular weakness |
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Epidemiology/associations w/polymyalgia rheumatica
|
Occurs in patients >50YO
Associated with temporal giant cell arteritis |
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Lab findings in polymyalgia rheumatica
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Incr ESR, normal CK
|
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Treatment of sarcoidosis
|
Steroids
|
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Treatment of polymyalgia rheumatica
|
Prednisone
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Symptoms of polymyositis
|
Symmetric proximal muscle weakness
Most often in shoulders |
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Etiology of polymyositis/diagnosis
|
CD8+ T cell induced injury to myofibers
Muscle biopsy w/evidence of inflammation is diagnostic |
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Dermatomyositis symptoms
|
Similar to polymyositis but it is has heliotrope rash
Shawl and face rash Gottron's papules |
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Lab findings in polymyositis/dermatomyositisi
|
Incr CK
Incr aldolase Positive ANA Positive Anti-Jo |
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Associations with dermatomyositis
|
Incr risk of malignancy
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Treatment for dermato/polymyositis
|
Steroids
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Scleroderma
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Excessive fibrosis and collagen deposition throughout the body.
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Complications of scleroderma
|
Sclerosis of renal, pulmonary, CV, and GI systems
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Diffuse scleroderma
(a) presentation (b) serum markers |
(a) widespread skin involvement, rapid progression, early visceral involvement
(b) anti Scl-70 ab (topisomerase I antibody) |
|
|
CREST
(a) presentation (b) serum markers |
(a) calcinosis, raynaud's phenomenon, esophgeal dysmotility, sclerodactyly, telangiectasia; limited skin involvement often confined to fingers/face; more benign
(b) anti centromere antibody |
|
|
Lipoma
(a) gross appearance (b) treatment |
(a) soft, well encapsulated fat tumor (benign)
(b) simple excision usually curative |
|
|
Liposarcoma
(a) description (b) treatment |
(a) malignant fat tumor that can be large
(b) will recur unless adequately excised |
|
|
Rhabomyosarcoma
(a) epidemiology (b) location |
(a) most common soft tissue tumor of childhood
(b) arises from skeletal muscle, most often in head/neck |
|
|
Embryonal rhabdomyosarcoma
(a) description (b) location |
(a) grape like soft polypoid apperance
(b) genitourinary or upper respiratory tract |
|
|
Define seronegative spondyloarthropathies (genetic associations and epidemiology)
Name the 3 diseases in this category |
Arthritis without RF
Strong association with HLA B27 (codes for MHC I) Occurs more in males Anklyosing spondylitis, Reiter's syndrome, Psoriatic arthritis |
|
|
Signs/symptoms of ankylosing spondylitis
|
Chronic inflammatory disease of spine and sacryoiliac joints; stiff spine due to fusion of joints; uveitis and aortic regurgitation seen; bamboo spine on x ray
|
|
|
Associations of anklyosing spondylitis
|
Inflammatory bowel disease
|
|
|
Classic triad of Reiter's syndrome
|
(1) conjunctivitis and anterior uveitis
(2) urethritis (3) arthritis |
|
|
Possible causative agent to Reiter's?
|
Chlamydia
|
|
|
Psoriatic arthritis presentation
|
Joint pain and stiffness associated w/psoriasis; asymmetric and patchy involvement
|
|
|
X ray signs of psoriatic arthritis
|
Dactylitis (sausage fingers)
"pencil in a cup" |
|
|
Why do SLE patients have false positives on RPR/VDRL syphilis tests?
|
Antiphospholipid antibodies cross react w/cardiolipin used in tests
|
|
|
Autoantibodies in SLE and their significance
|
(1) ANA (sensitive, not specific)
(2) anti dsDNA (very secific, poor prognosis) (3) anti-Smith (very specific but not prognostic) (4) antiHistone (drug induced lupus) |
|
|
Systemic lupus presentation
I'M DAMN SHARP |
Ig's (anti dsDNA, anti-Sm, andphospholipid)
Malar rash Discoid rash ANA Mucositis (oropharyngeal ulcers) Neurological disorders Serositis (pleuritis, pericarditis) Hematologic disorders Arthritis Renal disorders Photosensitivity |
|
|
Sarcoidosis associations
|
Gammaglobulinemia
RA ACE increase Interstitial fibrosis Noncaseating grabulomas |
|
|
Why is hypercalcemia seen in sarcoid
|
Elevated conversion of vitD to its active form in epithelioid macrophages
|
|
|
Signs/sx of sarcoidosis
|
Restrictive lung disease
Erythema nodosum Bell's palsy Hypercalcemia Uveoparotitis |
|
|
Polymyalgia rheumatica symptoms
|
Pain and stiffness in shoulder and hips, often with fever, malaise, wt loss
No muscular weakness |
|
|
Epidemiology/associations w/polymyalgia rheumatica
|
Occurs in patients >50YO
Associated with temporal giant cell arteritis |
|
|
Lab findings in polymyalgia rheumatica
|
Incr ESR, normal CK
|
|
|
Treatment of sarcoidosis
|
Steroids
|
|
|
Treatment of polymyalgia rheumatica
|
Prednisone
|
|
|
Symptoms of polymyositis
|
Symmetric proximal muscle weakness
Most often in shoulders |
|
|
Etiology of polymyositis/diagnosis
|
CD8+ T cell induced injury to myofibers
Muscle biopsy w/evidence of inflammation is diagnostic |
|
|
Dermatomyositis symptoms
|
Similar to polymyositis but it is has heliotrope rash
Shawl and face rash Gottron's papules |
|
|
Lab findings in polymyositis/dermatomyositisi
|
Incr CK
Incr aldolase Positive ANA Positive Anti-Jo |
|
|
Associations with dermatomyositis
|
Incr risk of malignancy
|
|
|
Treatment for dermato/polymyositis
|
Steroids
|
|
|
Scleroderma
|
Excessive fibrosis and collagen deposition throughout the body.
|
|
|
Complications of scleroderma
|
Sclerosis of renal, pulmonary, CV, and GI systems
|
|
|
Diffuse scleroderma
(a) presentation (b) serum markers |
(a) widespread skin involvement, rapid progression, early visceral involvement
(b) anti Scl-70 ab (topisomerase I antibody) |
|
|
CREST
(a) presentation (b) serum markers |
(a) calcinosis, raynaud's phenomenon, esophgeal dysmotility, sclerodactyly, telangiectasia; limited skin involvement often confined to fingers/face; more benign
(b) anti centromere antibody |
|
|
Lipoma
(a) gross appearance (b) treatment |
(a) soft, well encapsulated fat tumor (benign)
(b) simple excision usually curative |
|
|
Liposarcoma
(a) description (b) treatment |
(a) malignant fat tumor that can be large
(b) will recur unless adequately excised |
|
|
Rhabomyosarcoma
(a) epidemiology (b) location |
(a) most common soft tissue tumor of childhood
(b) arises from skeletal muscle, most often in head/neck |
|
|
Embryonal rhabdomyosarcoma
(a) description (b) location |
(a) grape like soft polypoid apperance
(b) genitourinary or upper respiratory tract |
