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273 Cards in this Set
- Front
- Back
Most common salivary gland tumor |
pleomorphic adenoma (Benign mixed tumor) |
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Most common malignant salivary gland tumor |
Mucoepidermoid carcinom
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Most common site for salivary gland tumors |
Parotid gland |
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Most common intraoral site for salivary gland tumors |
Palate |
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Bilateral parotid gland (most likely) M >> F |
Warthin’s tumor |
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Upper lip tumor (most likely)
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Monomorphic adenoma |
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Associated with pain due to perineural invasion |
Adenoid cystic carcinoma |
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Facial nerve paralysis
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Parotid malignant Salivary Gland tumors |
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Pleomorphic Adenoma (Parotid 69%, Asymptomatic swelling) |
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Pleomorphic Adenoma (Parotid 69%, Asymptomatic swelling)
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Pleomorphic Adenoma (multiple cells, chondroid, myxoid) |
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Pleomorphic Adenoma (multiple cells, chondroid, myxoid) |
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Pleomorphic Adenoma treatment |
Surgical excision Has potential to become malignant in 5%
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Pleomorphic Adenoma |
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Malignant Mixed Tumor (60-70 yo
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Overabundance of mitochondria = granularit
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Oncocytoma (Parotid 78% Older adults 50-70yo
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older smoking MALES
M>>>F 10:1 |
Papillary Cystadenoma Lymphomatosum (Warthin Tumor) |
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Papillary Cystadenoma Lymphomatosum (Warthin Tumor) - bilateral |
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Papillary Cystadenoma Lymphomatosum (Warthin Tumor)
Double row of oncocytes in Lymphoid stroma
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Upper lip Older Female
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Monomorphic Adenoma (Canalicular adenoma
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Minor salivary gland |
Canalicular Adenoma (upper lip older females) |
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Minor salivary gland |
Canalicular Adenoma (upper lip older females) |
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Parotid older female |
Basal Cell Adenoma |
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No association with HP
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Ductal Papillomas Sialadenoma papilliferum |
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Inverted Ductal papilloma |
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Only in the minor SG
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Inverted Ductal papilloma |
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Ductal epithelium line the projection
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Sialadenoma papilliferum |
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Papillary intraductal proliferation located beneath the mucosal surface |
Inverted Ductal papilloma |
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Mucoepidermoid Carcinoma |
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most common Salivary Gland maligancy in children parotid 48% |
Mucoepidermoid Carcinoma |
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Mucoepidermoid Carcinoma |
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Ductal and cystic spaces surrounded by mucous & squamous cell
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Mucoepidermoid Carcinoma |
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Mucoepidermoid Carcinoma |
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Most common and best-recognized intra-bony salivary tumor
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Intraosseous Mucoepidermoid Carcinoma |
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50% to 60% develop within the minor SG Slow growing PAINFUL mass Middle Aged
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Adenoid Cystic Ca |
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Swiss cheese” appearance +Neural Invasion
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Adenoid Cystic Ca |
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Adenoid Cystic Ca treatment |
excision radiation recurrence is high |
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Polymorphous Low Grade Adenocarcinoma PLGA |
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Minor SG only Older adults Painless Can erode underlying bon
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Polymorphous Low Grade Adenocarcinoma PLGA |
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Polymorphous Low Grade Adenocarcinoma PLGA |
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Polymorphous Low Grade Adenocarcinoma PLGA |
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Stensen's duct |
Parotid Gland (watery secretion)
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Wharton’s duct |
Submandibular Gland
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Bartholin’s duct |
Sublingual Gland
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Immune defense of saliva + digestion |
IgA Amylase |
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Drug-induced hyposalivation |
Anti-cholinergics
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Unstimulated saliva (which cells and glands) |
Basal production Mostly minor & submandibular outpu
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Stimulated saliva (which gland) |
Mostly Parotid |
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Salivary Gland Aplasia syndromes |
Treacher Collins Hemifacial Microsomia Syndrome
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Mucocele (lower lip more often) |
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Mucocele (lower lip more often) |
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No epithelial lining Granulation tissue lines the central space
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Mucocele (lower lip more often) |
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No epithelial lining Granulation tissue lines the central spac |
Mucocele (lower lip more often) |
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Mucoepidermoid Carcinoma |
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Ranula |
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Ranula |
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Ranula |
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Ranula |
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Ranula |
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Ranula |
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Ranula |
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Ranula |
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Mucus Retention Cyst (Salivary Duct cyst) |
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Lining converts to squamous epithelium (true cyst) Looks like mucocele More likely in cystic fibrosis |
Mucus Retention Cyst |
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Calcification Usually: submandibular gland duc
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Sialolithiasis |
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Sialolithiasis |
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Sialolithiasis |
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--Hyperparathyroidism -- Hypercalcemia
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Sialolithiasis |
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Sialolithiasis |
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Sialolithiasis |
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Sialolithiasis |
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Sialolithiasis |
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Sialolithiasis |
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Sialadenitis |
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Sialadenitis where first |
Infections of salivary glands
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puss coming out |
Sialadenitis |
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Sialadenitis |
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Sialadenitis |
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Cheilitis Glandularis (minor salivary glands of lip) Increased SCCA lower lip most often |
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Sjögren's syndrome |
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Immune attack against ductal cells Loss of tolerance in CD4+ T cells
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Sjögren's syndrome |
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Sjögren's syndrome 3 things |
Immune attack against ductal cells Loss of tolerance in CD4+ T cells |
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Sjögren's syndrome |
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Sjögren's syndrome |
Sicca syndrome (dry eyes) (dry mouth) – RA (rheumatoid arthritis) – SLE (systemic lupus erythematosus) |
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40x increased risk of non-Hodgkin B cell lymphoma |
Sjögren's syndrome |
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Lymphoepithelial Lesion |
HIV + Sjögren's syndrome |
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salivary gland enlargement, non-inflamatory |
Sialadenosis |
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bilateral or unilateral |
Sialadenosis |
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Sialadenosis (conditions associated) |
ENDOCRINE DISORDERS Nutritional Drugs
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rare lesion of minor salivary glands |
Adenamatoid Hyperplasia |
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locally destructive inflammatory condition |
Necrotizing Sialametaplasia |
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dental injection |
Necrotizing Sialametaplasia |
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Necrotizing Sialametaplasia |
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Necrotizing Sialametaplasia |
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Acinar necrosis |
Necrotizing Sialametaplasia |
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Lymphoid Hyperplasia (Cervical Lymphadenitis) |
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Lymphoid Hyperplasia (Cervical Lymphadenitis) |
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Lymphoid Hyperplasia (Cervical Lymphadenitis) |
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movable |
Lymphadenopathy infectious mononucleosis |
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draining |
Lymphadenopathy tuberculosis |
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Tonsillitis |
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Tonsillitis |
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Tingible bodies |
Tonsillitis |
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Hyperplastic Lingual Tonsil |
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Hyperplastic Lingual Tonsil |
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Hyperplastic Lingual Tonsil |
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keratin plugs |
Lymphoid hyperplasia
differen: (Tonsillolithiasis Actinomycosis - bacterial Lymphoepithelial cyst) |
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Tonsillolithiasis
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Lymphoid hyperplasia
differen: (Actinomycosis - bacterial Lymphoepithelial cyst keratin plugs) |
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teenagers and young adults
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lymphonodular Pharyngitis |
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Diffuse, apparently benign proliferation of lymphoid cells
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Benign Lymphoid Hyperplasia (Antibiotic therapy) |
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Hemophilia A |
classic clotting factor 8 x linked recessive |
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Hemophilia B |
clotting factor 9 Christmas disease x linked recessive |
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Von Willebrands hemaphilia |
Plasma glycoprotein that binds to VIII and aids in adhesion of platelet Autosomal dominant
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Pernicious Anemia (iron deficiency) |
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Anemias |
-Iron deficiency anemia -Pernicious anemia (Hypovitaminosis B12) -Folic acid anemia -Hemolytic anemia
Females >>> males
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Anemia |
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Anemia |
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Howell-Jolly Bodies |
Anemia |
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Horse shoe cell in bone marrow |
Anemia |
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Burning Tongue Syndrome |
Early Symptom of Vitamin B Deficiency |
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shovel shape fingernails (koilonychia) Atrophic Glossitis |
Iron Deficiency Anemia (no epi in these patients) |
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Plummer-Vinson Disease (Chronic, Severe Iron Deficiency ) |
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Plummer-Vinson Disease (Chronic, Severe Iron Deficiency ) |
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Plummer-Vinson Disease (Chronic, Severe Iron Deficiency ) |
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Blacks & Asians stepladder trabecular pattern hair on end skull |
Sickle Cell Anemia |
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Hematopoietic Precursor Cells diminished in bone marrow |
Aplastic Anemia (Neutropenia
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oral ulcers susceptible to infections |
Aplastic Anemia |
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Decrease in the number of the circulating neutrophils below 1500/mm3 in an adult
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Neutropenia |
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Uniformed spaced episodes of neutrophil deficiency Severe periodontal bone loss (premature)
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Cyclic Neutropenia |
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Cyclic Neutropenia |
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Defective gene for beta or alpha Hgb
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Thalassemia |
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Beta-thalassemia |
(2 genes involved): Thalassemia minor - one bad gene Thalassemia major - both genes are bad |
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Alpha-thalassemia |
(4 genes involved):
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Hair-on-end skull radiograph |
Thalassemia |
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Frontal bossing
Bone marrow hyperplasia =
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Thalassemia |
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increased brusing Petechiae and ecchymosis Fibrin deposits |
Thrombocytopenia (Decreased number of platelet) |
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increased brusing Petechiae and ecchymosis Fibrin deposits |
Thrombocytopenia (Decreased number of platelet) |
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Thrombocytopenia with AIDS |
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diascopy positive (blanching) |
Hereditary Hemorrhagic Telangiectasia |
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diascopy positive (blanching) |
Hereditary Hemorrhagic Telangiectasia |
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Hereditary Hemorrhagic Telangiectasia which genes? AD? HHT1-2. |
HHT1: endoglin gene mutation
AD
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Hereditary Hemorrhagic Telangiectasia |
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Dilated capillaries beneath epithelium
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Hereditary Hemorrhagic Telangiectasia |
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Hereditary Hemorrhagic Telangiectasia |
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Hereditary Hemorrhagic Telangiectasia |
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Leukemia |
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Leukemia |
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Leukemia |
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Leukemia in adluts in children |
adults CML older adults CLL - most common children ALL all ages AML |
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Leukemia |
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Leukemia treatment |
Bone marrow biopsy Treatment = Chemo CLL - incurable |
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Langerhans Cell Histiocytosis (first 2 decades of life, Posterior mandible ) |
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Langerhans Cell Histiocytosis |
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Proliferation of Langerhans cells
coffee bean shape |
Langerhans Cell Histiocytosis |
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Acute disseminated histiocytosis
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Letterer-Siwe disease |
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Chronic disseminated histiocytosis
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Hand-Schüller-Christian disease |
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bone and tooth loss that does not make sense |
Langerhans Cell Histiocytosis |
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Hodgkin's Lymphoma (Malignancy of B-cells) (Cervical & supraclavicular lymph nodes
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Unique tumor cell: Reed- -- A macrophage-like B-cell Binucleated :“owl eyes” |
Hodgkin's Lymphoma (Malignancy of B-cells) (Cervical & supraclavicular lymph nodes
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Hodgkin Disease nodular sclerosing (70%) MOST COMMON |
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Hodgkin Disease Lymphocyte rich |
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Non-Hodgkin's Lymphoma |
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Non-Hodgkin's Lymphoma |
85% B-cell type Most common form of lymphoma |
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Non-Hodgkin's Lymphoma |
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Non-Hodgkin's Lymphoma |
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Helicobacter pylori infection Epstein-Barr virus (EBV) Bloom syndrome
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Non-Hodgkin's Lymphoma |
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Non-Hodgkin's Lymphoma Mikulicz syndrome = lymphoma of |
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MALT lymphoma Non-Hodgkin's Lymphoma |
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MALT lymphoma Non-Hodgkin's Lymphoma |
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MALT lymphoma Non-Hodgkin's Lymphoma |
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MALT Lymphoma MALT = mucosa associated lymphoid tissue |
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MALT Lymphoma MALT = mucosa associated lymphoid tissue |
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MALT Lymphoma MALT = mucosa associated lymphoid tissue |
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MALT Lymphoma MALT = mucosa associated lymphoid tissue |
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Non-Hodgkin Lymphoma (Mandible >>> maxilla) |
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Non-Hodgkin Lymphoma (Mandible >>> maxilla) |
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Non-Hodgkin Lymphoma (Mandible >>> maxilla) |
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penny on the plate |
Non-Hodgkin Lymphoma (need immunohistochemistry) |
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Epstein-Barr virus in 90% of tumors |
Burkitt Lymphoma Maligna cy of B-Lymphocytes; Undifferentiated Lymphoma |
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Epstein-Barr virus in 90% of tumors Male >>females Posterior jaws
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Burkitt Lymphoma |
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Starry-sky appearance |
Burkitt Lymphoma |
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Burkitt Lymphoma |
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Proliferation of malignant T-cells |
Angiocentric T-Cell Lymphoma "midline lethal granuloma" |
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necrotic
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Angiocentric T-Cell Lymphoma |
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"midline lethal granuloma" |
Angiocentric T-Cell Lymphoma
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need immunohistochemistry |
Angiocentric T-Cell Lymphoma |
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CD4+ T-helper cells origin |
Mycosis Fungoides Cutaneous T-Cell Lymphoma Males >>> females
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Epidermotropism
CD4+ T-helper cells origin |
Mycosis Fungoides Cutaneous T-Cell Lymphoma Males >>> females
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Most common cutaneous lymphoma
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Mycosis Fungoides |
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Mycosis Fungoides |
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Mycosis Fungoides treatment |
no true cure Topical nitrogen mustard photochemotherapy
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Multiple Myeloma |
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60-70 yrs Multiple well defined RL Bence jones protein
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Multiple Myeloma |
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Sheets of malignant plasma cells with eccentric nuclei and stippled nuclear chromatin.
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Plasmacytoma |
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Hunter syndrome exhibits the characteristic facial features of this disorder
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Muccopolysaccharidosis
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Muccopolysaccharidosis |
-accumulation of glucosaminoglycans (impacted teeth) -macroglossia -thin enamel -gingival hyperplasia |
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Gaucher disease |
Lipid Reticuloendotheliosis (Results in an accumulation of the lipids within a variety of cells) |
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Gaucher disease Ashkenazi Jewish heritage
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Lipid Reticuloendotheliosis (Results in an accumulation of the lipids within a variety of cells) |
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Lack glucocerebrosidase Accumulation of glucosylceramide in lysosomes Bone pain accumulate glucosylceramide most common Lipid Reticuloendotheliosis |
Gaucher disease |
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Deficiency of acid sphingomyelinase death early accumulate sphyngomyelin
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Neimann-Pick Disease
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Lack of b-hexosaminidase A die in 3-5 years accumulation of ganglioside |
Tay-Sachs disease |
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Thickened papules are present along margin of the eyelid
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Lipoid Proteinosis |
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Deposition of waxy material in dermis and submucosal CT
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Lipoid Proteinosis |
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mucosa nodular, diffusely enlarged & thickened |
Lipoid Proteinosis |
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lamellar |
Lipoid Proteinosis |
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extracellular proteinaceous substance called amyloid
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Amyloidosis |
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macroglossia |
Amyloidosis
(deposition of amyloid protein) |
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Vitamin A Deficiency |
maintenance of vision growth and tissue differentiation |
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Vitamin B-Thiamin Deficiency (B1) |
Beriberi functioning of neurons |
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Vitamin B-Riboflavin Deficiency |
oxidation-reduction reactions
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Vitamin B-Riboflavin Deficiency |
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Vitamin B-Riboflavin Deficiency |
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Vitamin B-Niacin deficiency (B3) |
Pellagra = rough skin Triad of dermatitis, dementia, and diarrhea
stomatitis and glossitis, with the tongue appearing red, smooth, and raw
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Vitamin B-Pyridoxine Deficiency (B6) |
amino acid synthesis healthy brain function Signs = weakness, dizziness, seizure
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Vitamin C Deficiency |
scurvy Ascorbic acid is necessary for the proper synthesis of collagen
gingival swelling with sponataneous hemorrhage, ulceration, tooth mobility, severe perio
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Vitamin C Deficiency |
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Vitamin C Deficiency |
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Vitamin D Deficiency |
Rickets= infancy
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Vitamin E Deficiency |
A-tocopherol is a fat-soluble vitamin Liver disease antioxidant |
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Vitamin K Deficiency |
Clotting factor Coagulopathy Oral = increased gingival bleeding
Wide variety of green vegetables |
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Peutz-Jehger's Syndrome |
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Peutz-Jeghers Syndrome |
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Peutz-Jeghers Syndrome |
LKB1 gene
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Peutz-Jeghers Syndrome |
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Peutz-Jeghers Syndrome |
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Polyposis |
Peutz-Jeghers Syndrome |
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Addison’s (more wide) |
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Addison’s (more wide) |
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Tetracycline pigmentation |
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Tetracycline pigmentation |
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hypocalcification of the skeletal structures
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hypophosphatasia (Deficiency of tissue-nonspecific alkaline phosphatase)
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very linear ulcerations of the mandibular vestibule |
Crohn’s Disease |
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Crohn’s Disease (very linear ulcerations of the mandibular vestibule) |
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Cobblestone appearance of the mucosa, and deep granulomatous-appearing ulcers
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Crohn’s Disease |
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Nonnecrotizing granulomatous inflammation of submucosal CT
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Crohn’s Disease |
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Crohn’s Disease treatment |
-Sulfa type of drug (sulfasalazine)
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snailtrack |
Pyostomatitis Vegetans (Crohn’s & Ulcerative colitis) |
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Pyostomatitis Vegetans (snailtrack) |
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before and after dialysis |
Uremic Stomatitis |
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Uremic Stomatitis |
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Uremic Stomatitis |
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no eye lashes no eye brows no sweat glands Males >>>>> females can not regulate temperature |
Ectodermal Dysplasia |
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Ectodermal Dysplasia |
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Ectodermal Dysplasia |
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Ectodermal Dysplasia |
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Ectodermal Dysplasia oral presentation |
Oligodontia -- Diminished number of teeth |
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Ectodermal Dysplasia |
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Tuberous Sclerosis |
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Ungual or periungual fibromas |
Tuberous Sclerosis |
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Tuberous Sclerosis |
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shagreen patches Cardiac rhabdomyoma Disruption of the tumor suppressor activit hypopigmentation called ash-leaf spot
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Tuberous Sclerosis |
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Multiple, randomly distributed enamel pits
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Tuberous Sclerosis |
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Multiple Hamartoma Syndrome Cowden’s Syndrome |
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Multiple, irregular fibroepithelial papules involve the tongue and alveolar ridge mucos
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Multiple Hamartoma Syndrome Cowden’s Syndrome |
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Cowden’s Syndrome |
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-Most common Lipid Reticuloendotheliosis -Lack glucocerebrosidase -Accumulation of glucosylceramide |
Gaucher Disease |
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-type of Lipid Reticuloendotheliosis -Deficiency of acid sphingomyelinase -Accumulation of sphyngomyelin |
Neimann-Pick Disease |
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-type of Lipid Reticuloendotheliosis -Lack of b-hexosaminidase A
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Tay-Sachs Disease |
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What is the second most common cyst, is derived from degenerated stellate reticulum? |
Dentigerous cyst |
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Which lesion is associated with rosette structures (zellballen), hamartomas, young females, is located in the anterior maxilla, and is derived from reduced enamel epithelium? |
Adenamatoid Odontogenic Tumor (AOT) |
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Which lesion has a ground glass appearance and a mutation in GNAS 1 gene? |
Fibrous Displasia of the bone
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Which lesions are multilocular and have scalloped borders in the radiolucency? |
Central Giant Cell Granuloma and traumatic bone cyst |
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Which lesion derives from malignant neoplasm of neuroectodermal cells, is associated with young white males, and has moth eaten borders? |
Ewing sarcoma |
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Which lesion resembles a Cementoblastoma but is not attached to the root?
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Osteoblastoma |
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Which lesion is very painful but relieved with aspirin? |
Osteoid Osteoma |
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Which lesion is not relieved by aspirin? |
Osteoblastoma |
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Which lesion looks similar to mandibular tori? |
Osteoma |
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Starry sky appearance |
Burkitts lymphoma
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Eosinophilic Ghost Cells are characteristic of what kind of cyst? |
Calcifying Odont Cyst |
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Mutation of PATCH gene is assoc with what syndrome? |
Gorlin Syndrome |
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Reed-Sternberg Cells can be found in what kind of lymphoma? |
Hodgkin Lymphoma |
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Most common inherited disorder |
Thalassemia |
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hair on end skull (2 diseases) |
Thalassemia Sickle cell anemia |