How Uranium affects TP53 Do we know how Uranium affects TP53 to affect our bodies? Uranium is a dense radioactive metal, that is used as fuel in nuclear reactors. Uranium has several isotopes, and the most important of these, are radioactive and presented in nature. This radioactive substance affects our bodies in many contrasting ways. Examples are, our organs, DNA, our tissue, bones, and TP53 gene. In this paper, we will focus most on how Uranium affects TP53 to affect our body. The official name of the gene is tumor protein p53. It’s nicknamed the “guardian of the genome.” TP53 is what protects our cells from growing and dividing too fast, or uncontrollably. The gene has a very important location in the nucleus of our cells, where it binds directly to DNA. When DNA is
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Accounting for more than 90% of the cases is TCC. In the United States, about 45,000 men and 17,000 women are diagnosed with bladder cancer each year. Salivary gland cancer is a cancer that forms in tissues of the salivary gland. The salivary glands are classified as major and minor. The major salivary gland consist of the parotid, submandibular, and sublingual glands. The minor gland includes small mucus-secreting glands located throughout the palate, nasal and oral cavity.[1] Salivary gland cancer is rare, with 2% of head and neck tumors forming in the salivary glands, the majority in the parotid.[2]. Salivary gland neoplasms (SGN) has an annual global incidence of 0.4 to 13.5 cases per 100,000 individuals (ar).There are some symptoms to identify this disease. These symptoms include, fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. A painless lump in the affected gland is the most common type the SGN. Sometimes this can be accompanied by paralysis of the facial nerve. Sometimes there are several causes for this reason, uranium being one of them. In Salivary gland neoplasms (SGN), TP53 is located at 17p 13.1, and it is
Accounting for more than 90% of the cases is TCC. In the United States, about 45,000 men and 17,000 women are diagnosed with bladder cancer each year. Salivary gland cancer is a cancer that forms in tissues of the salivary gland. The salivary glands are classified as major and minor. The major salivary gland consist of the parotid, submandibular, and sublingual glands. The minor gland includes small mucus-secreting glands located throughout the palate, nasal and oral cavity.[1] Salivary gland cancer is rare, with 2% of head and neck tumors forming in the salivary glands, the majority in the parotid.[2]. Salivary gland neoplasms (SGN) has an annual global incidence of 0.4 to 13.5 cases per 100,000 individuals (ar).There are some symptoms to identify this disease. These symptoms include, fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. A painless lump in the affected gland is the most common type the SGN. Sometimes this can be accompanied by paralysis of the facial nerve. Sometimes there are several causes for this reason, uranium being one of them. In Salivary gland neoplasms (SGN), TP53 is located at 17p 13.1, and it is